Two subclones of L1210 murine leukemia (L1210-46.1 and L1210-56.3) were isolated in the absence of selective agents. Subclone 56.3 appeared to be more sensitive than was subclone 46.1 to treatment with dexamethasone, 1-/8-D-arabinofuranosyl cytosine, vincristine, and X-irradiatkxi. No differences between the parent cells and the two subclones could be observed in population-doubling time, cloni...

This investigation was concerned with the acute effect of ethionine, thioacetamide, dimethylnitrosamine (DMN), or aflatoxin B, on hepatic polyribosomes and protein synthesis of rats fed purified diets either ad libitum for 3 to 29 weeks containing 0.025% N-2-fluorenylacetamide (2FAA) or 0.06% 3 -methyl-4-dimethylaminoazobenzene (3 Me-DAB) or by force-feeding for 3 days of diets containing 2-FAA...

There is a wealth of evidence from both epidemiological studies (Hales and Barker, 2001) and animal models (Tarry-Adkins and Ozanne, 2016) that environmental exposures during early mammalian development may alter developmental trajectories in a manner that results in altered disease susceptibility and stress responsiveness in later life. This phenomenology is termed 'developmental programming.'...

Usubuchi sarcoma (US) is one of the methyicholanthrene-induced ascites tumors in the rat. It was established in 1953 by transforming a solid type tumor into the ascites type (Usubuchi et al. 1953). Since then, the US has been main tained over 1900 transfer generations in his laboratory by successive transfers. The chromosome investigations of the US have been made in some early stages before th...

HANDLING human chromosomes is my métier. I meric constrictions). This pivotal discovery in a cell culture laboratory on the Gulf Coast of Texas in the early realized that long ago; however, preparing an article for Perspectives led me to ask myself how this 1950s—that immersion of mitotic cells in a hypotonic medium will make the chromosomes suitable for microcame to be. I, like others who took...