replication, ‫5ف‬ bp per end per cell division, demonstrating that in Drosophila telomeric DNA is not neces-Department of Molecular Biology sary to protect an end from degradation (see for exam-without telomeric DNA appear to function normally, there is no deleterious consequence to the organism until the slow erosion due to incomplete replication Telomeres, the physical ends of eukaryotic chro...

OBJECTIVE To assess the knowledge of four groups of individuals regarding who is legally authorised to consent to health care or research involving older patients. DESIGN A provincewide postal survey. SETTING Province of Quebec, Canada. PARTICIPANTS Three hundred older adults, 434 informal caregivers of cognitively impaired individuals, 98 researchers in aging and 136 members of research ...

SUMMARY Acute and chronic effects of gonadotropin releasing hormone (GnRH) administration on reproductive characteristics of 32 rams have been assessed during the nonbreeding season. Rams injected intramuscularly with 50 /ag of GnRH had elevated (P<.01)concentrations of serum testosterone and noticeably higher (60%) mating activities when compared to control animals injected with saline. Daily ...

A utophagy is a process by which cellular components are captured into organelles called autophago-somes and then brought to the lysosome or vacuole to be broken down and recycled for other uses. It frequently comes into play during starvation, allowing cells to survive periods of privation. Yoshinori Ohsumi survived privation while growing up in post–World War II Ja-pan and struggled to establ...

observations, to constrain the pattern of N2 fixation across the Pacific Ocean. N2 fixation introduces isotopically light atmospheric N2 from to the ocean (d N = 0‰) relative to the oceanic average near 5‰, which makes nitrogen isotopes suitable to infer patterns of N2 fixation. Including atmospheric iron limitation of diazotrophy in the model shifts the pattern of simulated N2 fixation from th...

The hydroxylating activities of liver microsomes for proges terone and testosterone were markedly decreased in male and female rats bearing Walker carcinosarcoma 256. The decreases in the hydroxylating activities were greater in the male rats than in the female rats. The content of cytochrome P-450 in liver microsomes was decreased in the tumor-bearing male and female rats. Moreover, the bindin...

THIS IS NOT a review. It is an essay, conceived in the first place as a tribute to one of the founders of modern biology. Accordingly, it dwells over the past and considers tissue fracfionation mainly in its historical perspective. It does take a brief look at the present state of the art, mainly in order to give some sort of idea of what has been accomplished in the last 25 years thanks to the...

A lot of confusion and misunderstanding has been created by several commentators on the issue of non-performing loans (NPLs) of banking system. They take the absolute amount of such loans at the current point of time and compare it with the quantum of such loans in October 1999 and make a hue and cry that the situation has deteriorated because the quantum of NPLs has gone up. Such a simplistic ...

The marriage of quantum physics and information technology has the potential to generate radically new information processing devices. Examples are quantum cryptosystems, which provide guaranteed secure communication, and quantum computers, which manipulate data quantum mechanically and could thus solve some problems currently intractable to conventional (classical) computation. This introducto...

Universitä t Freiburg with the analysis of folding of specific endogenous proteins in mutant strains, these studies have led to signifi-Hermann Herder Str. 7 D-79104 Freiburg cant advances in our understanding of protein folding in the complex cellular milieu. Germany Nascent chains emerging at the peptide exit tunnel of Madison, Wisconsin 53706 the ribosome are awaited by a welcoming committee...