UNLABELLED There is an emerging paradigm that the human microbiome is central to many aspects of health and may have a role in preventing enteric infection. Entamoeba histolytica is a major cause of amebic diarrhea in developing countries. It colonizes the colon lumen in close proximity to the gut microbiota. Interestingly, not all individuals are equally susceptible to E. histolytica infection...

SFB 882 Working Papers are refereed scholarly papers. Submissions are reviewed by peers in a two-stage SFB 882 internal and external refereeing process before a final decision on publication is made. The Working Paper Series is a forum for presenting works in progress. Reviewers should communicate comments on the manuscript directly to the author(s). Whether fat or thin, male or female, young o...

A nanoparticle-based formulation of sorafenib (NP-sfb) significantly inhibited hepatocellular carcinoma by suppressing angiogenesis and promoting cytotoxic T lymphocyte infiltration.

Lung cancer is currently the leading cause of cancer-related deaths worldwide. In this study, we investigated the combination of carboxyamidotriazole (CAI) and sorafenib in non-small cell lung cancer (NSCLC) in vitro and in vivo to test whether CAI enhances the antitumor effects of sorafenib and reduces its side effects. The combination index (CI) showed that coadministration of CAI and sorafen...

This paper describes EXMARaLDA, a system for computer transcription of spoken discourse developed and used by the SFB "Mehrsprachigkeit" at the university of Hamburg. EXMARaLDA consists of several DTDs for XML coding of transcription data and some input and output tools for these formats. Apart from being a transcription system in its own right, EXMARaLDA also plays the role of a mediator betwe...

Set-up and maintenance of central data management systems in interdisciplinary research projects face some typical problems and challenges. Data management should be regarded as an integral and indispensable constituent of any multi-group project and must therefore be included from early on into the conceptual planning. Continuous and close communication between the system developing team and a...

We report on recent work on adaptive timestep control for weakly instationary gas flows [16, 18, 17] carried out within SFB 401, TPA3. The method which we implement and extend is a space-time splitting of adjoint error representations for target functionals due to Süli [19] and Hartmann [10]. In this paper, we first review the method for scalar, 1D, conservation laws. We design a test problem f...

Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute t...