Toward identifying molecules involved in cell-cell interactions during cerebral cortical development, we have investigated the nature of immunoglobulin-like immunoreactivity (Ig-ir) in the murine cortex. Immunohistochemistry using several antisera recognizing IgG revealed intense immunoreactivity in the subplate and marginal zone of embryonic day 16 cortex, as well as in the hindbrain and spina...

Progenitor-B cells recombine their immunoglobulin (Ig) loci to create unique antigen receptors. Despite a common recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner. We studied pre-pro-B cells and Rag(-/-) progenitor-B cells to determine whether Ig locus contraction or nuclear positioning is decisive for stepwise rearrangements. We found that both Ig loc...

INTRODUÇÃO: A terapia com oxigênio suplementar reduz quadros de hipóxia reduzindo a mortalidade entre recém-nascidos prematuros (RNPT), porém, excessiva exposição ao oxigênio, tem o potencial atingir e danificar múltiplos órgãos do neonato. Objetivo: Determinar os fatores associados uso suporte ventilatório/oxigenoterapia nos RNPT. MATERIAIS E MÉTODOS: Estudo observacional, longitudinal, prospe...

Dear MMTC fellow members, Welcome to the September issue of IEEE MMTC E-letter! Time really flies. This is the first time I write to you as the vice-chair of MMTC. First of all, I want to express my sincere gratitude to the E-letter and R-letter editorial teams as well as chairs and vice–chairs of special interest groups (IG), and all contributors over the past two years. Their contribution and...

Hapten-binding receptor material was isolated from sensitized rabbit lymphocytes by a method described previously for murine receptor material. The material was separated into a fraction expressing immunoglobulin determinants (anti-Ig+ fraction) and a fraction lacking known class and type-specific determinants of Ig constant domains (anti-Ig- fraction). We present evidence in support of the not...

Chemical s t r u c t u r e and m o le c u la r w e ig h t

Induction of switch recombination to the 3'1 and e immunoglobulin (Ig) heavy chain loci was examined in B cells preactivated with anti-Ig (B lymphoblasts). In B lymphoblasts cultured with interlenkin 4 (IL-4), IL-5 induced the accumulation of S/~-$3'1 rearrangements, but not e recombination. Thus, IL-5 facilitates switch recombination directed to the 3'1 heavy chain locus by IL-4, but additiona...

A series of synthetic oligosaccharides based on sialyl Lewis x (sLex; Neu5Ac alpha 2-3Gal beta 1-4[Fuc alpha 1-3]GlcNAc) and sialyl Lewis a (sLea; Neu5Ac alpha 2-3Gal beta 1-3[Fuc alpha 1-4]GlcNAc) was used to study the binding interactions of selectins. E-selectin-immunoglobulin fusion protein (E-selectin-Ig) bound to immobilized bovine serum albumin (BSA)-neoglycoproteins containing sLex or s...

T cell receptor (TCR) and variable region genes are assembled from germ-line gene segments located in a single chromosomal locus in which TCR segments are situated between TCR segments. The TCR enhancer (E ) located at the 3 end of the TCR locus functions over a long chromosomal distance to promote TCR rearrangement and maximal TCR expression; whereas the TCR enhancer (E ) is located among the ...