Introduction: Ordered subset expectation maximization (OSEM), is an effective iterative method for SPECT image reconstruction. The aim of this study is the evaluation of the role of system matrix in OSEM image reconstruction method using four different physical beam radiation models with three detection configurations. Methods: SPECT was done with an arc of 180 deg...

BACKGROUND Although quantitative analysis using standardized uptake value (SUV) becomes realistic in clinical single-photon emission computed tomography/computed tomography (SPECT/CT) imaging, reconstruction parameter settings can deliver different quantitative results among different SPECT/CT systems. This study aims to propose a use of the digital reference object (DRO), which is a National E...

OBJECTIVES The aim of this study was to evaluate the influences of reconstruction and attenuation correction on the differences in the radioactivity distributions in (123)I brain SPECT obtained by the hybrid SPECT/CT device. METHODS We used the 3-dimensional (3D) brain phantom, which imitates the precise structure of gray matter, white matter and bone regions. It was filled with (123)I soluti...

PURPOSE The aim of this article is to propose an exact SPECT region of interest (ROI) reconstruction method using truncated transmission and truncated emission data. METHODS Recently, the authors published two articles in Physics in Medicine and Biology with two results in SPECT ROI emission image reconstruction. The first result states that if the transmission data are truncated but the emis...

In recent years the development of cone-beam reconstruction algorithms has been an active research area in x-ray computed tomography (CT), and significant progress has been made in the advancement of algorithms. Theoretically exact and computationally efficient analytical algorithms can be found in the literature. However, in single photon emission computed tomography (SPECT), published cone-be...

We compare two different implementations of a 3D SPECT system model for iterative reconstruction, both of which compensate for non-uniform photon attenuation and depth-dependent system response. One implementation performs fast rotation of images represented using a basis of rectangular voxels, whereas the other represents images using a basis of rotationally symmetric volume elements. In our s...

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In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regio...

Abstract Prostate cancer is one of the most common cancers affecting men. Bone scan part staging modality commonly used to evaluate bone metastasis. A with diffused increased skeletal tracer uptake relative soft tissue, combined faint renal activity known as a superscan. However, primary concern are false negatives associated scans, where diffuse metastasis indistinguishable on superscans. In t...

Single photon emission computed tomography (SPECT) is based on the measurement of radiation emitted by a radiotracer injected into the patient. Because of photoelectric absorption and Compton scatter, the gamma photons are attenuated inside the body before arriving at the detector. A quantitative reconstruction must consider the attenuation, which is usually nonuniform. Novikov has derived an e...