The optical density ( 450 nm) of samples of homogenized fungal biomass correlated linearly with the dry weight of the biomass in the samples. As shown for broths of the filamentous microfungus Neurospora sitophila, the sensitivity of the technique depended on the extent of fragmentation of fungal hyphae during homogenization: increased fragmentation increased sensitivity. The method applied dur...

PURPOSE Ambrisentan (ABS) is an antihypertensive drug used in the treatment of pulmonary atrial hypertension. The survey of literature for ABS revealed only two spectrophotometric methods for its quantification. The reported methods lack the sensitivity. This study is aimed at developing two sensitive extractive spectrophotometric methods for the determination of ABS in bulk and in tablets. M...

Non-derivative and derivative UV spectrophotometric techniques using water as solvent have been developed for the simultaneous determination of amoxicillin and clavulanate in combined tablets. For UV spectrophotometric techniques, the concentrations of amoxicillin and clavulanate in conformity with the Lambert-Beer law are 100.0 – 160.0 mg/ml and 10.0 – 35.0 mg/ml, respectively. The derivative ...

The review is devoted for the solid phase extraction and the extractive spectrophotometric methods for the determination of some psychotropic drugs, e.g. phenothiazines, thioxanthenes, dibenzothiazines, fluoxetine, fluvoxamine, trazodone.

tidepressants, a group of drugs widely used for treating depressive diseases. Its chemical structure is shown in Fig. 1. Most existing methods for the determination of nortriptyline in bulk, pharmaceutical formulations and biological samples have been reviewed. Among other methods described for the assay of this drug are direct UV-spectrophotometry, derivatives spectrophotometry, fluorimetry an...

Accurate, precise and selective spectrophotometric and spectrofluorimetric methods were developed and subsequently validated for determination of Torasemide (I), Irbesartan (II) and Olmesartan medoxomil (III), where (I) could be determined in presence of its acidic-degradate as stability indicating method, utilizing derivative ratio spectrophotometry, also in human plasma it could be determined...

BACKGROUND Salicylic acid and its derivatives are widely used drugs with potential toxicity. The main areas of salicylate derivatives determination are biological liquids and pharmaceuticals analysis. RESULTS Silica-titania xerogel has been used for solid phase spectrophotometric determination of various salicylate derivatives (salicylate, salicylamide, methylsalicylate). The reaction conditi...

The reaction of aluminium(III) with Hydroxynaphtol Blue (HNB) in aqueous media at apparent pH 5.5 results in a red complex that is stable for at least 4 hr. Beer's Law is obeyed up to 1.6 microg/ml of aluminium(III) with an apparent molar absorptivity of 1.66 x 10(4) l.mol(-1). cm(-1) at 569 nm. This paper proposes procedures for aluminium(III) determination by ordinary and first-derivative spe...