We explore the forces and conservation laws that govern motion of a hockey puck slides without friction on smooth, rotating, self-gravitating spheroid. The earth's oblate spheroidal shape (apart from small-scale surface features) is determined by balancing gravitational hold it together against centrifugal try to tear apart. earth achieves this when apparent force puck, defined as vector sum fo...

Despite earlier studies demonstrating characteristics of colon cancer stem cells (CCSCs) and the role of epithelial-mesenchymal transition (EMT) in tumor development, it remains controversial as to the relationship between CCSCs and EMT. In this study, in order to present an insight into this relationship in colon cancer, we developed HCT116 and HT29 sphere models, which are known to be the cel...

Liver tissue engineering is hampered by poor implanted cell survival due to inadequate vascularization and cell-cell/cell-matrix interactions. Here, we use liver progenitor cell (LPC) spheroids to enhance cell-cell/cell-matrix interactions, with implantation into an angiogenic in vivo mouse chamber. Spheroids were generated in vitro in methylcellulose medium. Day 2 spheroids were optimal for im...

Malignant mesothelioma is an aggressive tumor arising from mesothelial cells of serous membranes, and forms spheroid-like cell aggregates in pleural and peritoneal effusions. We examined the levels of anoikis, apoptosis induced by the detachment of cells from the extracellur matrix, in suspension culture in the human mesothelioma cell line NCI-H2052. NCI-H2052 cells were adherent in conventiona...

Mesenchymal stem cells (MSCs) are capable of regenerative and immunomodulatory functions in cell-based therapies in a variety of human diseases and injuries; however, their therapeutic efficacy and potential side effects remain major obstacles in clinical applications. We report here a 3D spheroid culture approach to optimize stem cell properties and therapeutic effects of human gingiva-derived...

I argue that there are two modes of global star formation. Disks and smaller spheroids form stars relatively inefficiently as a consequence of supernova-triggered negative feedback via a sequence of ministarbursts (S mode), whereas massive spheroids formed rapidly with high efficiency via the impact of AGN jet-triggered positive feedback (J mode) that generates and enhances ultraluminous starbu...

It has been recognized that bystander effect is one of the key factors for radiobiological effects, particularly in low-dose region. Although <1% of cell nuclei were actually traversed by an alpha particle, 30% of the cells showed an increased frequency of sister chromatid exchanges at very low dose (0.31 mGy) of alpha particles exposed to a CHO culture dish [1]. Since then, a number of studies...

Oscillation modes of rapidly rotating stars have not yet been calculated with precision, rotational effects being generally approximated by perturbation methods. We are developing a numerical method able to account for the deformation of the star by the centrifugal force and, as a first step, we determined the acoustic modes of a uniform density spheroid and studied how the spheroid flatness af...