Objective: The present study aims to prepare stains-loaded enteric-coated pellets by extrusion and spheronization technique for acidic environment protection improve the viability of strains during storage. Methods: Lactobacillus casei plantarum are proven have various therapeutic prophylactic uses in human beings, but low stability storage transit site action has limited their action. Pellets ...

The present work aims to predict drug release from novel site-specific release isoniazid pellets, in USP dissolution test apparatus 3, using the response surface methodology (RSM). Site-specific release isoniazid pellets were prepared by extrusion-spheronization followed by aqueous coating of Acryl-EZE. RSM was employed for designing of the experiment, generation of mathematical models and opti...