OBJECTIVES Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. MATERIALS AND METHODS Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. ...

The most frequent clinical manifestation of vertebral artery dissection is posterior headache or neck pain accompanied or followed by posterior circulation transient ischemic attack or stroke. Rarer clinical features include isolated headache or neck pain, cervical spinal cord ischemia and cervical root impairment. Asymptomatic vertebral artery dissections have been reported. In the case of pri...

Functional resistance to graded hypotensive ischemia of various segments of the somatosensory pathway was determined in anesthetized cats by repeated concurrent recordings of regional blood flow measured by hydrogen clearance, and evoked potentials (EPs), of dorsal horn of lumbar spinal cord and cerebral cortex. During normal resting CNS blood flow (CBF), there were significant successive reduc...

one reported series, the 5-year survival rate for patients with spinal cord injury was 44%, whereas it was 62% for those without spinal cord injury.19 Postoperative spinal cord injury is caused by several factors including ischemia, reperfusion injury, and postoperative hemodynamics. Many methods of protecting the spinal cord during thoracoabdominal aneurysm repair have been devised. These incl...

BACKGROUND Spinal cord ischemia with resulting paraplegia remains one of the most common complications after repair of thoracoabdominal aortic aneurysms or dissection. Inducible nitric oxide synthase (iNOS) is known to have both neuroprotective and neurotoxic effects in the central nervous system. We investigated the possible relationship between the effect of pre-ischemic isoflurane exposure o...

POSTOPERATIVE paraplegia resulting from spinal cord ischemia is a devastating complication of thoracic aneurysm (TA) or thoracoabdominal aortic aneurysm (TAAA) surgery. Permanent neurologic deficits are a major cause of morbidity and may shorten long-term survival. Factors that are associated with the development of paraplegia are previous aortic surgery, preoperative renal function, age, aorti...

Introduction. Neurogenic stunned myocardium (NSM) is a reversible cardiomyopathy resulting in transient left ventricular apical ballooning presumed to result from catecholamine surge occurring under physiologic stress. Acute spinal cord ischemia is a rare ischemic vascular lesion. We report a case of neurogenic stunned myocardium occurring in the setting of acute spinal cord infarction. Methods...

INTRODUCTION Sudden tetraparesis represents a neurological emergency and is most often caused by traumatic spinal cord injury, spinal epidural bleeding or brainstem ischemia and less frequently by medial disc herniation or spinal ischemia. CASE PRESENTATION Here we report the rare case of an 82-year-old Caucasian man who developed severe tetraparesis four days after radical cystoprostatectomy...

Background and Purpose: The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the eifects of pretreatment with flunarizine on systemic hemodynamics, spinal cord blood ...

Ulinastatin (UTI), a trypsin inhibitor, is isolated and purified from human urine and has been shown to exert protective effect on myocardial ischemia reperfusion injury in patients. The present study was aimed at investigating the effect of ulinastatin on neurologic functions after spinal cord ischemia reperfusion injury and the underlying mechanism. The spinal cord IR model was achieved by oc...