Poly(ADP-ribose) polymerase, (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the tissue injury associated with stroke and neurotrauma. The aim of our study was to evaluate the therapeutic efficacy of in vivo inhibition of PARP in an experimental model of spinal cord trauma, which was induced by the application of vascular clips (force of 24 g) to the dura ...

spinal traumatic injuries are the major damage which is associated with morbidity and mortality rates. in this study the epidemiological characteristics of spinal trauma and their outcome were investigated. in this cross sectional study, trauma patients who admitted to imam reza hospital were included. their information such as age, sex, type of injury, severity of injury and site of injury was...

Poly(ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the tissue injury associated with stroke and neurotrauma. The aim of our study was to evaluate the therapeutic efficacy of in vivo inhibition of PARP in an experimental model of spinal cord trauma, which was induced by the application of vascular clips (force of 24g) to the dura vi...

BACKGROUND This study was wanted to investigate the prevalence of concomitant injuries among hospitalized acute spinal trauma patients aged 20 and over and the effects of those injuries on medical utilization in Taiwan. METHODS Nationwide inpatient datasets of Taiwan's National Health Insurance (NHI) database from between 2000 and 2003 were used. The major inclusion criteria used to select ca...

In the setting of spinal trauma, the bone, ligaments, spinal cord, and vascular structures may be injured. Anatomically, the vertebral bony spine can be divided into structural columns. The cervical spine is traditionally divided into two columns— anterior and posterior. The anterior column consists of the load-bearing vertebral bodies, intervertebral disks, anterior longitudinal ligament, and ...

Spinal cord infarction (SCI) is a rare but devastating disease that occurs in association with trauma or predisposing cardiovascular risk factors. Since clinical presentation variable, it remains diagnostic challenge patients without factors, often mistaken for other diseases. Delay diagnosis of SCI can result missed treatment opportunities and contributes to the high case fatality rate. This r...

This article reviews aspects of management of traumatic brain and spinal cord injury. A discussion of management of intracranial pressure after traumatic brain injury is followed by a discourse on cerebrovascular trauma and pediatric injuries. Specific management methods are discussed, including medical and surgical management in intracranial hypertension. A special attempt is made to include t...

BACKGROUND Although spinal cord injuries are frequent causes of myelopathy in young patients, stab wounds of the spinal cord rarely occur and are typically maximal symptomatic immediately after the trauma. CASE DESCRIPTION A 31-year-old male developed delayed onset of symptoms 4 years after a stab wound to the cervical spinal cord attributed to a plant needle (plant called Mandacaru). Followi...

Spinal cord injury is a debilitating neurological disorder that initiates a cascade of cellular events that result in a period of secondary damage that can last for months after the initial trauma. The ensuing outcome of these prolonged cellular perturbations is the induction of neuronal and glial cell death through excitotoxic mechanisms and subsequent free radical production. We have previous...

s, letters, comments, editorials, reviews, or surveys Animal and in vitro studies Languages other than English Study published before 1995 No trauma (e.g., disease-related spinal cord lesions) Studies dealing with radiology protocols for cervical spine clearance Inclusion Criteria Studies were included if BOTH of the following criteria were met: Traumatic spinal cord injury or suspected spinal ...