The nucleotide excision repair (NER) pathway is central in response to damage induced by environmental carcinogens. Efficiency of this pathway, probably genetically determined, may modulate individual risk of developing squamous cell carcinoma of the head and neck (SCCHN) as well as second primary malignancy (SPM) after the index tumor. We hypothesized that common non-synonymous and regulatory ...

Despite a real risk of overturning, for the Self-Propelled agricultural Machinery (SPM) the ROPS approach to protect the driver is rather recent. Due to the several SPM categories available on the market, characterized by very different mass, dimension and working functions, the fitting of a ROPS and consequently the check of its strength is complicated. The SPM could be preliminarily divided i...

The accurate measurement of suspended particulate matter (SPM) concentrations in coastal waters is of crucial importance for ecosystem studies, sediment transport monitoring, and assessment of anthropogenic impacts in the coastal ocean. Ocean color remote sensing is an efficient tool to monitor SPM spatio-temporal variability in coastal waters. However, near-shore satellite images are complex t...

The Sand Pile Model (SPM) and its generalization, the Ice Pile Model (IPM), originate from physics and have various applications in the description of the evolution of granular systems. In this article, we deal with the enumeration and the exhaustive generation of the accessible configuration of the system. Our work is based on a new recursive decomposition theorem for SPM configurations using ...

A series of SPM VIII analogs were synthesized to investigate the effect of the amino acid moiety on the antitumor activity. The L-threonine analog and the glycylglycine analog of SPM VIII showed much higher cytotoxicity to P388 murine leukemia cells (IC50 5.8 nM and 0.11 nM, respectively) than SPM VIII (IC50 25nM). However, replacement of the glycine moiety with other amino acids greatly reduce...

This paper proposes a sequential pattern mining (SPM) algorithm in large scale uncertain databases. Uncertain sequence databases are widely used to model inaccurate or imprecise timestamped data in many real applications, where traditional SPM algorithms are inapplicable because of data uncertainty and scalability. In this paper, we develop an efficient approach to manage data uncertainty in SP...

Previous studies have led to the hypothesis that some proteins of the postsynaptic membrane are locally synthesized at postsynaptic sites. To evaluate this hypothesis, synaptosome fractions that included fragments of dendrites were allowed to incorporate labeled amino acid into protein. The labeled synaptosomes were then subfractionated to the level of the synaptic plasma membrane (SPM) and the...

This note describes ANOVAs and how they can be implemented in SPM. For each type of ANOVA we show what are the relevant statistical models and how they can be implemented in a GLM. We give examples of how main effects and interactions can be tested for using F-contrasts in SPM. We also show how to implement a repeated-measures M-way ANOVA with partitioned errors using a two-level procedure in SPM.

We derive a theoretical model for studying SPM feedback in the context of control theory. Previous models presented in the literature that apply standard models for proportional-integral-derivative controllers predict a highly unstable feedback environment. This model uses features specific to the SPM implementation of the proportional-integral controller to give realistic feedback behaviour. A...

This paper presents an initial study to perform Iarge-vocabuIary continuous Mandarin speech recognition based on a Segmental Probability Model(SPM) approach. SPM was first proposed for recognition of isolated Mandarin syllables, in which every syllable must be equally segmented before recognition. Therefore, A concatenated syllable matching algorithm in place of the conventional Viterbi search ...