We read with great interest the recent article by Yang et al. regarding their primate model investigating optic neuropathy resulting from reduced cerebrospinal fluid pressure. The authors conducted a thorough case-control study looking at the effects of intracranial hypotension from insertion of a lumbar-peritoneal shunt in four rhesus monkeys, adding five control monkeys with lumbar-peritoneal...

The outcome of spontaneous intracranial hypotension has been unpredictable. The results of initial MRI were correlated to outcome of treatment in 33 patients with spontaneous intracranial hypotension. A good outcome was obtained in 25 (97%) of 26 patients with an abnormal MRI vs only 1 (14%) of 7 patients with a normal MRI (p = 0.00004). These findings show that normal initial MRI is predictive...

The imaging characteristics of spontaneous intracranial hypotension have been well described in the clinical and imaging literature. We present a case of spontaneous intracranial hypotension with typical clinical and laboratory features that were thought to be suspicious for a ruptured aneurysm. Blood in the CSF in conjunction with headaches led to cerebral angiography that showed diffuse enlar...

Subarachnoid Space Opacification on Delayed Postcontrast Fluid-Attenuated Inversion Recovery Imaging in Spontaneous Intracranial Hypotension: Visualizing the Monro-Kellie Hypothesis Intracranial volume compensatory changes explained by the MonroKellie hypothesis (MKH) occur in spontaneous intracranial hypotension (SIH) and may be seen on MR imaging. This case illustrates previously unreported f...

OBJECTIVE Spontaneous intracranial hypotension (SIH) is most commonly caused by cerebrospinal fluid (CSF) leakage. Therefore, we hypothesised that patients with orthostatic headache (OH) would show decreased optic nerve sheath diameter (ONSD) during changes from supine to upright position. METHODS Transorbital B-mode ultrasound was performed employing a high-frequency transducer for ONSD meas...

BACKGROUND AND PURPOSE In reviewing MR images of patients with spontaneous intracranial hypotension (SIH), we found an accentuated decrease in the subcortical white matter on fluid-attenuated inversion recovery (FLAIR) images. Our aim was to determine whether the signal intensity of the subcortical white matter decreases on FLAIR and T2-weighted images in SIH. MATERIALS AND METHODS We retrosp...

Purpose: We evaluated the MRI finding of pachymeningeal enhancement in patients with intracranial hypotension and head trauma with particular attention to differential findings and change in follow-up study, and in order to support the knowledge about the pathophysiology of d ural enhancement. Materials and Methods : The findings of enhanced brain MRI offifteen patients who showed diffuse pachy...

From the Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Department of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan. Received January 10, 2005. Revised and Accepted January 21, 2005. Reprint requests and correspondence to: Sung-Tsang Hsieh. MD. Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. ...

The majority of cases of spontaneous intracranial hypotension (SIH) result from spontaneous cerebrospinal fluid (CSF) leaks. The disorder has a broad clinical and imaging spectrum, with substantial variability in clinical and imaging features, in CSF findings, and in response to treatment. Headache is the most common symptom, and is typically orthostatic, but with chronicity the orthostatic fea...

Spontaneous intracranial hypotension is a rare benign and usually self-limited condition of unknown aetiology. Four cases are presented that illustrate how the MRI features may support a diagnosis suggested on clinical grounds. The MRI findings include diffuse symmetric smooth dural thickening and enhancement, not only at the cranial level, but also involving the cervical spinal dura, subdural ...