Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG island methylation in colorectal cancer, we have used a recently developed technique called methylated CpG island amplification to examine 30 newly cloned differentially methylated DNA sequences. Of these 30 clones, 19 (...

BACKGROUND Young-onset colorectal cancer is uncommon, but the incidence is increasing. Despite several guidelines for colonoscopic surveillance following colorectal cancer resection, there is little consistency regarding the timing and age-adjusted strategies of surveillance colonoscopy after surgery of young-onset colorectal cancer. The aim of this study was to compare the outcomes of surveill...

The genetic basis of sporadic colorectal cancer has illuminated our knowledge of human cancer genetics. This has been facilitated and catalyzed by an appreciation and deep understanding of the forms of colorectal cancer that harbor an inherited predisposition, including familial adenomatous polyposis (FAP), hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome, the hamartomatous p...

Colorectal cancer (CRC) is one of the most common cancers and one of the leading causes of cancer death in the Western world. The disease arises from the accumulation of mutations in oncogenes, tumor suppressor genes and mismatch repair genes during progression from normal colon epithelium to adenoma and metastatic carcinoma. The majority of colorectal cancers arise in sporadic form. About one-...

Colorectal cancer is one of the leading causes cancer-related death worldwide. The adenomatous polyposis coli (APC) gene mutated in hereditary colorectal tumors and more than 80% sporadic tumors. APC mutations impair ?-catenin degradation, to its permanent stabilization increased transcription cancer-driving target genes. In colon cancer, impairment degradation leads cytoplasmic accumulation, n...

Colorectal cancer is one of the most common malignancies and the most dreadful long-term complication in patients with ulcerative colitis. The incidence rate of colorectal cancer ranks second among the malignancies all over the world, and the number is still rising. Amid the many risk factors for colorectal cancer, ulcerative colitis is becoming increasingly prominent. The risk of colorectal ca...

The serum protein markers of colorectal adenoma in patients with a family history of colorectal cancer have been rarely reported. Serum samples from colorectal adenoma patients with or without a family history of colorectal cancer and healthy controls were profiled using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS). The model to distinguish colorec...

Colorectal cancer is undoubtedly one of the most genetically studied malignancies. In the past 20 years, substantial progress has been made in understanding the genetic and molecular pathogenesis of this cancer. It is instructive that the genes involved in the inherited colon cancer syndromes are the same genes involved in the etiology of most colorectal cancers. Familial adenomatous polyposis ...

abstract introduction: in recent years, many studies employed and found an association between type 2 diabetes mellitus and colorectal cancer. although increased risk of colorectal cancer in individuals with non insulin dependent diabetes mellitus (niddm) has been observed in previous studies, limited information is available on the colorectal cancer associated with niddm in iran. the purpose o...

 Metastatic ovarian cancers occur in 3-8 percent of women undergoing surgical resection of a primary colorectal cancer. In this study we examined the characteristics of women with colorectal cancer for whom synchronous oophorectomy had been performed. In this cross-sectional study, records of patients with colorectal cancer from April 1991 through October 1999 who had undergone surgery for both...