Evidence obtained from experiments with rats and mice is presented suggesting that the naturally occurring amino acids putreanine and N8-(2-carboxyethyl)spermidine, and most probably also related compounds deriving from the polyamines spermidine and spermine by oxidative metabolism, are formed within two anatomical compartments. In the first step polyamines are converted into aldehydes by serum...

Novel 3-C-alkylated-Neu5Ac2en derivatives have been designed to target the expanded active site cavity of influenza virus sialidases with an open 150-loop, currently seen in X-ray crystal structures of influenza A virus group-1 (N1, N4, N5, N8), but not group-2 (N2, N9), sialidases. The compounds show selectivity for inhibition of H5N1 and pdm09 H1N1 sialidases over an N2 sialidase, providing e...

PURPOSE We investigated reliability, construct validity, and feasibility of two sprint tests for children with cerebral palsy (CP). METHODS Twenty-six children with CP participated (7-18 years of age; Gross Motor Function Classification System [GMFCS] level I or II). On different occasions, the 10 x 5-Meter Sprint Test and the Muscle Power Sprint Test were scored by different assessors. RES...

In this paper we examine sprint-driven software development as it occurs in a specific Open Source community, PyPy. Applying a situated learning perspective, we report the findings from a study focused on the activities leading up to, taking place during, and following after sprints. The study included analyses of sprint reports, email archives and other documents available on the community web...

This investigation describes the sprint performances of the highest internationally ranked professional male road sprint cyclist during the 2008-2011 Grand Tours. Sprint stages were classified as won, lost, or dropped from the front bunch before the sprint. Thirty-one stages were video-analyzed for average speed of the last km, sprint duration, position in the bunch, and number of teammates at ...

this study aimed to assess the effects of four weeks of detraining after eight weeks of intense sprint training on risk factors of atherogenic inflammatory damages. for this purpose, 42 male rats were divided randomly into two groups: sprint training group (experimental) (n=24 and weight 210±7) and control group (n=18 and weight 211±3). the training program was performed for 12 weeks, three ses...

The specific objectives of this study were to determine whether sprint performance in juvenile rainbow trout is correlated with either voluntary swimming activity or aggressive behaviors and to determine the reciprocal: the effect of swimming activity and aggression on sprint performance. Sprint performance was assessed by rapidly accelerating trout (5-7-cm fork length) to a fixed velocity (40,...

PURPOSE This study aimed to determine the pattern of neuromuscular fatigability that manifests during repeated-sprint running exercise. METHODS Twelve male participants (mean ± SD: age, 25 ± 6 yr; stature, 180 ± 7 cm; body mass, 77 ± 7 kg), currently training and competing in intermittent sprint sports, performed a repeated maximal sprint running protocol (12 × 30 m, 30-s rest periods). Pre- ...

Methods Physically active male and female volunteers (n = 13) completed 24 × 50 yard sprints following NEC and DC (counterbalanced). Sprints were completed in 2 halves (12 sprints per half) with 2 minutes recovery between each sprint and a 10-minute recovery period between halves. Acute-RPE (A-RPE) (0–10 omni scale) was recorded after every sprint and Session RPE (S-RPE) was recorded 20 min aft...