Steel, concrete, peanut butter, and genetic testing all have something in common: all have reference material established in the National Institute of Standards and Technology (NIST), an agency within the U.S. Department of Commerce (Pear, 2015). On May 21, 2015, NIST announced that they made ‘‘the world’s first reference material to help ensure laboratories accurately ‘map’ DNA for genetic tes...

Any modeling language can be said to model variability, but our concern is how variability can be expressed generically and thus be standardized on its own and not as an add-on or profile to other languages. In product line engineering feature modeling has been applied to express variants of product models. This paper shows how the Common Variability Language can be designed to enhance feature ...

Building biological understanding of the Chinese Hamster Ovary (CHO) system used to manufacture therapeutic proteins is paramount to efficient CHO bioprocess optimization. This understanding can be built by analyzing and synthesizing biological data; such as transcriptomic (gene expression), proteomic (protein levels), or metabolomic (metabolite levels). This thesis describes a streamlined work...