background and objective: bhitarkanika is the mangrove ecosystem of orissa, india. it was not explored before for occur  rence and distribution of streptomyces . with the aim of isolation and characterization of special group of bacteria from this mangrove ecosystem, the present study has been made. materials and methods: isolates of streptomyces were obtained from plant, soil and water collect...

Sir: We have established a screening system for differentiation inducing substances of animal cells1). Using this system, we have recently isolated a new substance from culture filtrate of a streptomycete, which induces differentiation of mouse leukemia cells. The active substance was named differenol A. Streptomyces sp. ANS-127, the differenol Aproducing organism was isolated from a soil sampl...

An attempt was made to verify the observation that Streptomyces griseus was prevalent in soil based on isolation work. A genus-specific PCR was developed for Streptomyces based on the housekeeping gene atpD and used to investigate species diversity within selected soils. The presence of S. griseus was investigated to determine coexistence of resistance-only streptomycin phosphotransferase (strA...

An earlier paper (Lechevalier, Acker, Corke, Haenseler, and Waksman, 1953), announcing the addition of candicidin to a rapidly growing list of antifungal antibiotics, described the morphological and cultural characteristics of Streptomyces griseus 3570, from which candicidin originated, its selective antibiotic action, and methods by which the agent itself could be isolated from culture broths ...

During the course of screening inhibitors from microorganisms for platelet aggregation, we found that an isochromanequinone antibiotic medermycin isolated from the cultured broth of Streptomyces sp. KM-1 1749 possessed a potent anti-platelet activity. In this paper, we wish to describe the fermentation, isolation, and in vitro and in vivo anti-platelet activities of medermycin and its related a...

Sir: During the course of screening for antiviral antibiotics from microorganisms isolated from soil samples we found that pentalenolactones isolated from the fermentation broth of Streptomyces sp. OM-2718 possess potent antiviral activities. In this paper, we wish to describe the production, isolation and selective antiviral activities of pentalenolactones, especially the specific antiviral ac...

Among the antitumor drugs, bacterial enzyme L-asparaginase has been employed as the most effective chemotherapeutic agent in pediatric oncotherapy especially for acute lymphoblastic leukemia. Glutaminase free L-asparaginase producing actinomycetes were isolated from soil samples collected from Egypt. Among them, a potential culture, strain NEAE-119, was selected and identified on the basis of m...

Mutanolysin biosynthesis and pigment production in Streptomyces globisporus ATCC 21553 were stimulated by adding bacterial cell walls to the medium. The increased bacteriolytic activity in the supernatant correlated with an increased de novo synthesis of mutanolysin and was between 4- and 20-fold higher than in cultures grown without bacterial cell walls. The increase in mutanolysin synthesis w...

Actinomycetes were isolated from different organs viz. skin, gills and gut contents of three species of fishes viz. Mugil cephalus (Linnaeus, 1758), Chanos chanos (Forskal, 1775) and Etroplus suratensis (Bloch, 1780) using three different media from the Vellar estuary, situated along the southeast coast of India. Among the three fishes, M. cephalus harboured highest number of actinomycetes popu...