The current text provides a brief overview and a methodological appraisal of the systematic review and metaanalysis conducted by Samad and colleagues (2012) who assessed the clinical utility and diagnostic accuracy of CTA for the diagnosis of acute coronary syndrome (ACS) in low to intermediate risk patients presenting to the emergency department (ED) with acute chest pain of suspected cardiac ...

Articles reporting the diagnostic accuracy of non-invasive prenatal diagnostic (NIPD) tests for RHD genotyping using fetal material extracted from maternal blood have been published steadily for over a decade. Health care providers in Europe have started to use this technology for management of the small number of sensitised pregnancies (ca. 220-600 per annum in the Netherlands, Germany, France...

In a recent paper by Coban and colleagues (6), two colorimetric methods for early detection of vancomycin and oxacillin resistance in Staphylococcus aureus were reported. The authors state that the results were compared by calculating essential agreement, absolute agreement, and minor, major, and very major errors, as recommended by the FDA (10). However, in the cited version of the FDA documen...