Thiourea-based iminophosphorane (BIMP) organocatalysts featuring SPhos- or BIDIME phosphine units have been developed and successfully applied in the asymmetric addition of nitromethane to N-Boc-protected trifluoromethyl aryl ketimines. α-Trifluoromethyl β-nitroamines were obtained 40–82% isolated yields 80–95% enantioselectivities. A careful evaluation catalytic activity BIMPs indicates that c...

A novel nucleotide building block for enzymatic synthesis of azide modified DNA and subsequent conjugation via Staudinger ligation was developed.

The copper-catalyzed [3+2] azide-alkyne cycloaddition and the Staudinger ligation are readily applicable and highly efficient for the immobilization of cobalt Schiff base complexes onto polystyrene resins. Stepwise synthesis of polymer-bound Schiff bases followed by their subsequent complexation with metal ions were successfully carried out. Direct covalent attachment of preformed homogeneous c...

The genus Protarchanara Beck, 1999 is revised. The new genus Hydredes gen. n. (type species Hydredes yakobsoni sp. n.) is described. Three new species, Hydredes yakobsoni sp. n., H. shchetkini sp. n. and Protarchanara mythimnoida sp. n. are described from Central Asia. Two species, Arenostola delattini Wiltshire, 1953 and Hydraecia praecipua Hacker & Nekrasov, 2001 are transferred to the genus ...

Two 5 modified 2'-deoxyuridin triphosphates and a 7 modified 2'-deoxy-7-deazaadenosine were synthesized carrying a terminal azide linked to the base. For probing the sterical influence on incorporation and Staudinger ligation different sized flexible linkers were chosen. All three nucleotides can completely replace their natural counterparts in primer extension as well as polymerase chain react...

The Staudinger ligation between an azido-protein and a phosphinothioester-derivatized surface is demonstrated to be an effective means for the site-specific, covalent immobilization of a protein. Immobilization yields of >50% are obtained in <1 min, and immobilized proteins have >80% of their expected activity. No other method enables more rapid immobilization or a higher yield of active protei...

Chemical synthesis harbors the potential to provide ready access to natural proteins as well as to create nonnatural ones. The Staudinger ligation of a peptide containing a C-terminal phosphinothioester with a peptide containing an N-terminal azide gives an amide with no residual atoms. This method for amide bond formation is orthogonal and complementary to other ligation methods. Herein, we de...

We describe three new species: Zebeeba orzolae Falck &amp; Karsholt, sp. n. (Erebidae: Rivulinae), Nyctobrya vilfredi (Noctuidae: Bryophilinae) and Agrotis corralejoi Noctuinae). The unknown female of Mniotype loslobensis (Fischer, Saldaitis Ivinskis, 2007) Hadeninae) its genitalia are described illustrated. Twelve species recorded as to the fauna Canary Islands: Epharmottomena eremophila (Rebe...