OBJECTIVE Brucine was encapsulated into stealth liposomes using the ammonium sulfate gradient method to improve therapeutic index. MATERIALS AND METHODS Four brucine stealth liposomal formulations were prepared, which were made from different phosphatidylcholines (PCs) with different phase transition temperatures (T(m)). The PCs used were soy phosphatidylcholine (SPC), dipalmitoyl phosphatidy...

The use of liposome as an adjuvant and a vaccine carrier has been cited previously in the literature. It has also been shown to be effective in enhancing the immunogenicity of vaccine candidates. BALB/c mice immunized subcutaneously with outer membrane protein (OMP) of Brucella abortus S19 vaccine strain entrapped in a commercial cationic liposome (S19-OMP-liposome) for vaccine delivery, showed...

Erlotinib (ELT) as a small molecule with poor solubility, poor bioavailability, and instability in gastrointestinal environment, has been considered as a therapeutic agent for Non-Small-Cell Lung Cancer (NSCLC) therapy through oral administration. In the present study, ELT-liposome and ELT-NLCs were successfully prepared and characterized by assessment of the particle size, zeta potential (ZP),...

Cutaneous leishmaniasis is caused by different species of Leishmania parasites and its available treatments have not yet provided a strong consistent result. The weak response of current chemotherapeutics is due to their deficient effects on stealth parasites inside macrophages, rapid clearance from the site of action and systemic side effects in high doses. Liposomal formulation of anti-leishm...

Enemy observers, such as cameras and guards, are common elements that provide challenge to many stealth and combat games. Defining the exact placement and movement of such entities, however, is a non-trivial process, requiring a designer balance level-difficulty, coverage, and representation of realistic behaviours. In this work we explore systems for procedurally generating both camera and gua...

Structural noise is an important factor that endangers aircraft fatigue life and flight safety. It also has a negative effect on aircraft stealth performance and noise navigability. An optimal design of a structure-acoustic coupled system is an effective way to reduce noise and vibration. Due to the uncertainties that exist in the structural and acoustical parameters, the traditional determinis...

This study investigates variations in how users exert agency and control over their choice patterns within the game-based ITS, iSTART-2, and how these individual differences relate to performance. Seventy-six college students interacted freely with iSTART-2 for approximately 2 hours. The current work captures and classifies variations in students’ behavior patterns using three novel statistical...

objective(s): soluble leishmania antigens (sla) provide suitable protection against leishmaniasis in murine model when delivered by an appropriate delivery system. liposomes have been shown to be suitable vaccine delivery systems against leishmaniasis, however, the phospholipase-a (pla) activity of sla is a drawback to prepare a stable liposomal sla. one strategy to overcome this problem might ...