نتایج جستجو برای: stereoselectivity
تعداد نتایج: 1551 فیلتر نتایج به سال:
A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.
The easily accessible haloalkynes can be converted to (Z)-2-halo-1-iodoalkenes in high yields with excellent regio- and stereoselectivity. The method shows good functional group compatibility. The resulting products could find broad applications.
Pd-catalyzed reaction of N-tosylhydrazones with benzyl halides affords di- and trisubstituted olefins in high yields with excellent stereoselectivity. This coupling reaction is supposed to proceed through a migratory insertion of Pd carbene species.
The total synthesis of cyanolide A has been achieved in 14 steps from commercially available (S)-2-ethyloxirane, exploiting the palladium-catalyzed intramolecular alkoxycarbonylation as the key step to construct the tetrasubstituted cis-tetrahydropyran ring with high stereoselectivity.
Brine provides remarkable rate acceleration and a higher level of stereoselectivity over organic solvents, due to the hydrophobic hydration effect, in the enantioselective Michael addition reactions of 1,3-dicarbonyls to β-nitroolefins using chiral H-donors as organocatalysts.
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