Stererotaxic surgery in rodents provides a valuable means to produce lesions of particular neuronal pathways, allowing scientists to examine the effects of these lesions on the subsequent behavior of animals post-surgery. A well-known application of this approach is the creation of unilateral dopamine-depleted rats using a stereotaxic injection of the neurotoxin 6-hydroxydopamine (6-OHDA) into ...

the present study was performed to evaluate the analgesic effect of morphine microinjection into the cuneiformis nucleus (cnf) and the effect of inactivation of this area by lidocaine on pain modulation. rats were anaesthetized by thiopental (45-60 mg/kg/i.p.) and placed in a stereotaxic instrument, and then a guide cannula was implanted just one mm above the cnf. following surgery and recovery...