Regulation of growth cone and cell motility involves the coordinated control of F-actin dynamics. An important regulator of F-actin formation is the Arp2/3 complex, which in turn is activated by Wasp and Wave. A complex comprising Kette/Nap1, Sra-1/Pir121/CYFIP, Abi and HSPC300 modulates the activity of Wave and Wasp. We present the characterization of Drosophila Sra-1 (specifically Rac1-associ...

All of the Azorhizobium, Bradyrhizobium, and Rhizobium genes known to be involved in the development of nitrogen-fixing legume root nodules are genes that code for proteins. Here we report the first exception to this rule: the sra gene; it was discovered during the genetic analysis of a Bradyrhizobium japonicum Tn5 mutant (strain 259) which had a severe deficiency in colonizing soybean nodules....

BACKGROUND Lidocaine can promote the apoptosis of eosinophils, which is normally delayed by IL-5; it has a good effect on serious steroid resistant asthma (SRA). The study aimed to explore the effect of nebulized lidocaine inhalation on asthma. METHODS It was a randomized, double-blind, placebo-controlled and prospective study. A total of 36 patients with acute asthma were divided into groups...

s of Communications Meeting of the Biochemical Society Steroid Group held at Imperial College, London, 1 July 1975 HORMONAL. REGULATION OF MACROMOLECULAR SYNTHESES : a Colloquium organized by W. I. P. Mainwaring (London) The Influence of Androgen-Receptor Complexes on Transcription by Rat and Human Prostatic Ribonucleic Acid Polymerases PETER DAVIES Tenovus Institute for Cancer Research, Welsh ...

BACKGROUND Although hypertension is an important risk factor for the development of atherosclerosis, the mechanisms for this interaction are incompletely described. Previous studies have suggested that biomechanical strain regulates macrophage phenotype. We tested the hypothesis that biomechanical strain can induce expression of the class A scavenger receptor (SRA), an important lipoprotein rec...

the objective of this study was to determine the effect of estradiol on mrna levels encoding fsh receptor (fshr), lh receptor (lhr), estrogenic and progestagenic enzymes. briefly, follicles between 2 and 5 mm diameter were dissected from the ovaries of adult cows collected from a local abattoir, cells were collected by rinsing the follicle walls with dulbecco modified eagle medium/f12 (dmem/f12...

background: molecular biomarkers are valuable in evaluation the course of malignancies. in this study, the relationship be­tween her2/neu, p53, steroid receptors and clinicopathological features of patients with breast cancer has been assessed. methods : three hundred thirty nine women with a primary diagnosis of breast cancer from 2001 to 2006 were included. they were evaluated for tumor featu...

Steroid hormones such as estrogens and androgens are important regulators of reproduction, physiology, and development in a variety of animal taxa, including vertebrates and mollusks. Steroid hormone receptors, which mediate the classic cellular responses to these hormones, were thought to be vertebrate specific, which left the molecular mechanisms of steroid action in invertebrates unresolved....