Toxic epidermal necrolysis (TEN) and Steven-Johnson syndrome (SJS) are characterized by extensive necrosis and cleavage of the epidermis from the dermis akin to a superficial or partial thickness burn. Sepsis is the usual cause of mortality but much of the pathophysiologic process results from an outpouring of cytokines and matrixmetalloproteinases (MMPs) which have a destructive effect on the ...

Given the increasing prevalence of tuberculosis, antitubercular drugs frequently used are also associated with ocular toxicity. Ethambutol is the most commonly implicated drug. It is generally well tolerated, but known to cause optic neuritis, more specifically retro bulbar neuritis causing blurred vision, decreased visual acuity, central scotomas, and loss of red-green color vision. The exact ...

Zin Lin,1,* Thomas Alcorn,2 Marko Loncar,1 Steven G. Johnson,2 and Alejandro W. Rodriguez3 1School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA 2Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA 3Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA (Receive...

Po-Ru Loh, ∗ Ardavan F. Oskooi, Mihai Ibanescu, Maksim Skorobogatiy, and Steven G. Johnson Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 Center for Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 OmniGuide Communications, One Kendall Square, Building 100 No. 3, Cambridge MA 02139 Génie Physique, École Polytech...

Objective: There are various adverse drug reaction (ADR) associated with pharmacological therapy that differ in clinical presentation, prognosis and therapy. Among these, cutaneous eruptions are the most common type of all ADRs.Theclinical presentation of cutaneous drug eruptions ranges from common transient and benign erythema to the most severe forms such as Steven-Johnson syndrome (SJS), Tox...

Saad Zaheer, Alejandro W. Rodriguez,* Steven G. Johnson, and Robert L. Jaffe Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Center for Theoretical Physics and Laboratory for Nuclear Science, Massachusetts Institute of Technology, Cambridge, Massachusetts...

Steven M. Silverstein and Brian P. Keane Division of Schizophrenia Research, University Behavioral HealthCare, University of Medicine and Dentistry of New Jersey, 151 Centennial Avenue, Piscataway, NJ 08854; Department of Psychiatry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ; Center for Cognitive Science, Rutgers University, New Bruns...

Introduction: Steven-Johnson syndrome (SJS) is an acute reaction that typically involves the skin and mucous membranes which are characterized by damage flaking of skin, accompanied pain, can cause death. Toxic epidermal necrolysis (TEN) a rare, life-threatening usually caused medication,which widespread erythema, necrosis, bullous detachment epidermis membranes, resulting in exfoliation possib...