Sun, Jianzhuo. M.S.A.A., Purdue University, May 2014. Biaxial Shear/Tension Failure Criteria of Spectra single fibers. Major Professor: Weinong Chen. An experimental study was conducted to develop the biaxial failure surface criteria of single Spectra 130d and 100d filaments in a torsion-tension environment. The crosssectional profiles of single Spectra fibers were investigated using scanning e...

Collagen is a key structural component of extracellular matrix and its mechanical properties, particularly its stiffness, have been shown to influence cell function. This study explores the mechanical behavior of type I collagen gels at low rates relevant to that of cell motion. The Young's modulus, E, was obtained for collagen samples of concentrations 1.3, 2 and 3 mg/ml at varying crosshead d...

Twenty-five fresh frozen flexor digitorum profundus tendons stratified by sex were subjected to uniaxial step stress and cyclic loads in twelve intact human cadaver hands. By attaching specially designed clip strain gage transducers on tendons just proximal and distal to an undisrupted carpal tunnel, the interactions of the tendons, tendon sheath and retinacula were measured. The elastic and vi...

For most force measurement applications, the strain gage based transducer can be relied upon to faithfully convert a mechanical input into a proportional electrical analog output signal. However, when the mechanical input is either applied or changes at a rapid rate, the sensor may distort the conversion and the user should be aware of the possible consequences of this distortion. This article ...

We used GAGE as a molecular marker to identify melanoma cells with metastatic potential in the peripheral blood and the bone marrow. One hundred thirty-three patients with malignant melanoma (21 clinical stage II, 74 stage III, and 38 stage IV) had a single marrow and/or blood sample drawn immediately prior to surgical resection. Simultaneous bone marrow and blood samples (85 patients), marrow-...

We explored the use of multiple molecular markers to overcome tumor heterogeneity. Sixty-seven neuroblastoma (NB) tumors were tested for the expression of GAGE, MAGE-1, MAGE-2, MAGE-3, and MAGE-4 by reverse transcription-PCR. Eighty-two percent of 67 NB tumors had detectable GAGE, and 88% expressed at least one of the four MAGE genes. By combining GAGE and MAGE, we found that 64 of 67 (95%) of ...