نتایج جستجو برای: stz induced diabetic rats

تعداد نتایج: 1249609  

Journal: :journal of basic and clinical pathophysiology 2013
zari sabet mehrdad roghani maryam najafi zahra maghsoudi

background and objective: teucrium polium (tp) has shown hypoglycemic effect in type 1 diabetes induced by single high dose of the cytotoxic agent streptozotocin (stz) in rats. this study was conducted to evaluate whether its aqueous extract could have such an effect in multiple low-dose stz-induced model of type 1 diabetes in rats. materials and methods: male wistar rats were divided into cont...

Journal: :British journal of pharmacology 1998
A Makino K Kamata

1. Both the plasma endothelin-1 (ET-1) levels and the plasma glucose levels were markedly elevated in streptozotocin (STZ)-induced diabetic rats. 2. The maximum contractile response of the mesenteric arterial bed to ET-1 was significantly reduced, and the vasodilatation induced by the ET(B)-receptor agonist IRL-1620 in the mesenteric arterial bed was significantly reduced in STZ-induced diabeti...

Journal: :Pharmacology, biochemistry, and behavior 2012
Gema Vera Visitación López-Miranda Esperanza Herradón María Isabel Martín Raquel Abalo

Diabetic neuropathy is a frequent complication of diabetes mellitus with a tremendous impact on patients' quality of life, and it remains poorly treated. Cannabinoids relieve the signs of diabetic neuropathy in different experimental models, including streptozotocin- (STZ-) induced type 1 diabetic rodents, and they may also relieve neuropathic signs in type 2 diabetic animals. This study compar...

Journal: :British journal of pharmacology 2000
T Kobayashi T Matsumoto K Kamata

1. We investigated the effects of chronic pravastatin treatment on the impaired endothelium-dependent relaxation seen in aortae from established streptozotocin (STZ)-induced diabetic rats. Starting at 6 weeks of diabetes, pravastatin (10 mg kg(-1)) was administered to STZ-induced diabetic rats for 4 weeks. 2. The increased total cholesterol and low-density lipoprotein (LDL) cholesterol levels s...

Diabetes mellitus is a common endocrine disorder. Anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. Berberis integerrima is a medicinal shrub used in conventional therapy for a number of diseases. The aim of the present study was to investigate the effects of aqueous extract of Berberis integerrima root (AEBI) on some physiological paramete...

Journal: :British journal of pharmacology 2000
A Makino K Ohuchi K Kamata

Experiments were designed to investigate the mechanisms underlying the diabetes-related impairment of the vasodilatations of the perfused mesenteric arterial bed induced by acetylcholine (ACh) and K(+). In streptozotocin (STZ)-diabetic rats, the ACh-induced endothelium-dependent vasodilatation was attenuated. The dose-response curves for ACh in control and diabetic rats were each shifted to the...

2015
Chih-Wei Tsao Chin-Yu Liu Tai-Lung Cha

Objective: This study investigated the effect of resistant maltodextrin (RMD) on reproduction in streptozotocin (STZ)-induced type 2 diabetic male rats. Methods: Forty male rats were induced with diabetes by a single intraperitoneal injection of STZ (50 mg/kg) and nicotinamide (100 mg/kg). Five groups were analyzed in total: normal, Diabetic rats without RMD, diabetic rats with RMD 1.2 g/100 g ...

Journal: :Iranian biomedical journal 2008
Zahra Heidari Mehdi Harati Hamid Reza Mahmoudzadeh-Sagheb Bita Moudi

BACKGROUND Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. In this study, protective effects of sodium tungstate against STZ-induced beta-cell damages were investigated. METHODS Sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic ra...

Azam Aliasghari Veshareh, Maryam Khezri, Mohammad Rabbani Khorasgani, Saeed Ahmadi Majd, Sayed Rasoul Zaker,

Objective: The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)-induced diabetic rats. This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of STZ-induced diabetic rats. Materials and Methods: For diabetes in...

Background: The experimental model of streptozotocine (STZ)-induced diabetes explains changes in the male reproductive system as part of the disease. Objective: The aim of the present study was to evaluate the olive leaf extract effects on STZ-induced diabetes and to examine its modulatory effects on sperm quality. Methods: Twenty adult male Sprague–Dawley rats were divided into four equal grou...

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