Polyhexamethylene biguanide (PHMB) is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. There are regulatory concerns with regard to its safety in humans for water treatment. We decided to assess the safety of this chemical in Sprag...

Various studies on Phragmanthera incana (mistletoe) did not intensify toxicity. Toxicological evaluation of Phragmanthera incana, a species of mistletoe growing on two plant hosts namely Cocoa (Theobroma cacao) and Kolanut (Cola nitida) in South-western Nigeria was carried out with the observation of Wistar rats’ haematological and serum biochemical changes for a period of thirty-day administra...

Lagenaria siceraria is traditionally being used in many countries in the treatment of various diseases including diabetes. The aim of the present study was to evaluate the safety of the methanol extract of L. siceraria aerial parts (MELS) through acute and subchronic toxicity study in mice. For acute toxicity study 5002000 mg/kg MELS were administered orally and obvious toxic symptoms and morta...

The root of Polygala tenuifolia Willdenow has been used for the treatment of insomnia, depression, and amnesia. However, the toxicological properties of the herb have been overlooked, because it has been used for a long time for various purposes. In this study, we evaluated the preclinical safety of the root extract in rats and beagle dogs. First, the acute oral toxicity was tested in both rats...

ETHNOPHARMACOLOGICAL RELEVANCE Maydis stigma (corn silk) has a long history of use as a traditional herbal medicine or functional food in China and many other countries and has been listed in the Chinese Pharmacopea. However, little data about its potential toxicity is available. AIM OF THE STUDY In this study, we evaluated the subchronic toxicity and genotoxicity of the flavonoid-rich extrac...

AIM OF THE STUDY To investigate subchronic toxicity and pharmacokinetic of wogonin using Beagle dog and to provide foundation for clinical applications of this promising anticancer agent. MATERIALS AND METHODS Wogonin was administered via intravenous infusion at dosages of 60, 30 and 15 mg/kg per day for 90 days followed by subchronic toxicity studies including general body parameters, hemato...

AIM The present study was performed to investigate acute and subchronic oral toxicity of Ferula assa-foetida gum (28 days) in Sprague Dawley rats. MATERIALS AND METHODS Acute oral administration of F. assa-foetida was done as a single bolus dose up to 5 g/kg in mice and subchronic toxicity study for 28 days was done by oral administration at doses of 0 (control) and 250 mg/kg in Sprague Dawle...

During the last two decades triterpenes have attracted attention because of their pharmacological potential. Triterpene extract (TE) from outer bark of birch consisting mainly of betulin is able to form an oleogel which was successfully tested in the treatment of actinic keratosis. Some aspects of TE in vitro pharmacology are already known. Now we show preliminary pharmacokinetics of betulin an...