BACKGROUND Sublingual and vaginal routes of misoprostol have been found to be effective for pharmacological ripening prior to surgical termination of first trimester abortions. We conducted this study to compare the effectiveness and acceptability of sublingual versus vaginal route of misoprostol for cervical priming prior to vacuum aspiration (VA). METHODS In this prospective clinical trial,...

The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms). After intravenous administration, the pharmacokinetic profile could be described with a two-compartment model. The distribution half-life was 0.049 +/- 0.10...

Allergen specific immunotherapy, together with drugs and allergen avoidance, is a cornerstone in the management of respiratory allergy. The traditional subcutaneous route is burdened with the risk of severe adverse events; therefore, safer routes of administration (noninjection or local routes) have been investigated and developed. Controlled trials failed to demonstrate the clinical efficacy a...

Prohormones such as 19-norandrostenediol (estr-4-ene-3beta,17beta-diol) have been added to the list of prohibited substances of the World Anti-Doping Agency because they are metabolized to the common nandrolone metabolites norandrosterone and noretiocholanolone. So far, no studies on the metabolism and in vivo conversion of 19-norandrostenediol after oral or sublingual administration have been ...

PURPOSE Sublingual buprenorphine and combination buprenorphine/naloxone (BNX) are effective options for the treatment of opioid dependence. A BNX sublingual tablet approved by the US Food and Drug Administration for the induction and maintenance treatment of opioid-dependence in adults was developed as a higher-bioavailability formulation, allowing for a 30% lesser dose of buprenorphine with bi...

Sixteen postmenopausal women underwent electrophysiologic study before and 20 minutes after the administration of sublingual estradiol 17beta or placebo. Estradiol 17beta significantly affected electrophysiologic parameters, thereby suggesting its role in the development of palpitations in women.

BACKGROUND Slow coronary flow (SCF) is slow dye progression in the coronary arteries during selective angiography, but there is no such study about greater visceral vessels. Studies have suggested that flow-mediated dilation (FMD) is impaired in SCF. Endothelial function can be assessed by FMD in the brachial artery as ischemia-induced vasodilation. Since inflammation is an underlying pathology...

The sublingual mucosa is an appealing route for drug administration. However, in the context of increased use therapeutic proteins, development protein delivery systems that will protect bioactivity needed. As proteins are fragile and complex molecules, current formulations liquid dosage. Yet, dilution short residence time at main barriers control dose delivered. In this work, a simple scaffold...

Introduction Despite technical progress, coronary magnetic resonance imaging (MRI) still faces multiple challenges including low SNR and small vessel size. Coronary vasodilators, such as sublingual nitroglycerin (NTG) or longer acting nitrates (e.g., isosorbide dinitrate), are commonly used to study coronary circulation. Terashima et al. [1] reported on the impact of sublingual NTG on coronary ...

lingual long-acting nitrates more prolonged than that achieved by nitroglycerin. It is likely that the duration of action of the sublingual nitrates is not as long as would be ideal, merely more prolonged than that achieved by nitroglycerin: a 1-21/2 hour duration of action seems most likely. Evidence that oral "long-acting nitrates" have a prolonged duration of action is, we agree, lacking. Al...