The neuroleptic malignant syndrome (NMS) commonly occurs on treatment with neuroleptics, it is also reported in patients who suddenly stop drugs like levodopa, amitriptyline and imipramine. We report a case of NMS, which occurred in a patient on lithium, haloperidol and trihexyphenidyl (THP) after sudden discontinuation of THP. The cholinergic system, through its effect on the dopaminergic syst...

OBJECTIVES Our aim was to review the evidence for a reduction in the risk of sudden infant death syndrome (SIDS) with pacifier ("dummy" or "soother") use, to discuss possible mechanisms for the reduction in SIDS risk, and to review other possible health effects of pacifiers. RESULTS There is a remarkably consistent reduction of SIDS with pacifier use. The mechanism by which pacifiers might re...

BACKGROUND To report the association between thoracic duct ligation and acute pancreatitis. The association between sudden stop of lymphatic flow and pancreatitis has been established in experimental models. CASE PRESENTATION A 57-year-old woman operated for thymoma presented a iatrogenic chylothorax. After thoracic duct ligation, she presented an acute pancreatitis which resolved after conse...

We report a patient with a bilateral optic anterior ischemic neuropathy as an extrahepatic complication of a chronic hepatitis C (HCV) infection. The patient presented with a bilateral visual acuity loss and bilateral optic disc oedema. The optic neuropathy was associated with a sudden increase in the viral HCV load after a recent liver transplantation. The stop of the calcineurin inhibitor had...

A novel SCN5A mutation was found in a child with congenital sick sinus disease, a Brugada-like electrocardiogram and recurrent aborted sudden death. The mutation (L1821fs/10) is a 4 base pair deletion (TCTG) at position 5464-5467 in exon 28 of the gene. The novel mutation is predicted to produce a frameshift leading to a premature stop codon after ten missense amino acids upstream that did not ...

QUESTION I often prescribe domperidone to women as a galactagogue starting at a dose of 30 mg and increasing the dose as needed. In March of this year, Health Canada released an advisory warning of domperidone use and abnormal heart rhythms and sudden cardiac death. Should I cap doses at 30 mg or stop prescribing domperidone all together to these women? ANSWER The Health Canada warning is bas...

introduction: natural and unexpected death that happens within less than one hour of first symptom occurrence is called sudden death. cardiovascular diseases are the main known reason of sudden death and more than 75% of sudden deaths in athletes are assigned to it. here we reported the autopsy results of all cases with sudden death following exercise that were referred to forensic center of te...

regular participation in intensive physical exercise is associated with electro-morphological changes in the heart.   this benign process is called athlete’s heart. athlete’s heart resembles few pathologic conditions in some aspects. so differentiation of these conditions is very important which otherwise may lead to a catastrophic event such as sudden death. the most common causes of sudden de...

Rare or narrowly distributed species may be threatened by stressors to which they have never been exposed or for which data are very limited. In such cases the species response cannot be predicted on the basis of directly measured data, but may be inferred from the response of one or more appropriate surrogate species. Here, I propose a practical way to use the stressor response of one or more ...