INTRODUCTION Radical orchiectomy (RO) is still considered the standard of care for malignant germ cell tumours, which represent the vast majority of the palpable testicular masses. In those patients diagnosed with small testicular masses (STMs), testis-sparing surgery (TSS) could be an alternative treatment to RO. The aim of this updated review is to evaluate the current indications for TSS, an...

Genetic toggle switches (TSs) are one of the best studied small gene regulatory networks (GRNs), due to their simplicity and relevant role. They have been interpreted as decision circuits in cell differentiation, a process long hypothesized to be bistable, or as cellular memory units. In these contexts, they must be reliable. Once a "decision" is made, the system must remain stable. One way to ...

Toxic shock syndrome (TSS) is a rare but life-threatening multisystem disease known to develop in the early postoperative period after various surgery. We report a rare case in which a patient who underwent Caesarean section developed TSS caused by methicillin-resistant Staphylococcus aureus (MRSA) on the 39th postoperative day. She was treated with debridement because of the possible diagnosis...

Identifying bacterial promoters is the key to understanding gene expression. Promoters lie in tightly constrained positions relative to the transcription start site (TSS). Knowing the TSS position, one can predict promoter positions to within a few base pairs, and vice versa. As a route to promoter identification, we formally address the problem of TSS prediction, drawing on the RegulonDB datab...

Limited evidence has been obtained concerning the beneficial effects of autologous serum therapy in treatment of skin disorders particularly chronic urticaria. In the present study, we have assessed the effect of this treatment method in patients with chronic urticaria (CU). This randomized single-blind controlled trial was performed on fifty consecutive patients with chronic urticaria. The pat...

Diagnosis of nonmenstrual staphylococcal toxic shock syndrome (TSS) is often challenging. A female medical colleague had a rare entity, a staphylococcal pharyngitis complicated by TSS. The diagnosis was confirmed by isolation of tst-positive Staphylococcus aureus in throat culture and by identification of a specific Vβ2 expansion pattern of her T lymphocytes. Recent improvements in microbiology...

We present our proposal for a small X-ray mission DIOS (Diffuse Intergalactic Oxygen Surveyor), consisting of a 4-stage X-ray telescope and an array of TES microcalorimeters, cooled with mechanical coolers, with a total weight of about 400 kg. The mission will perform survey observations of warm-hot intergalactic medium using OVII and OVIII emission lines, with the energy coverage up to 1.5 keV...

CONTEXT According to current guidelines, radical orchidectomy is the standard treatment for testis tumours of malignant and unknown origin. Testis-sparing surgery (TSS) has recently been proposed as an alternative option in selected cases. OBJECTIVE Our aim was to analyse the cumulative evidence for TSS in the treatment of adult malignant tumours of different histology, including notes on ope...

Alkaline/surfactant/polymer (ASP) flooding has been extensively applied to enhancing oil recovery. As an oil displacement agent, pe1troleum sulfonate (PS) is widely used in ASP pilot experiments. It is very important to find a petroleum sulfonate with a high interfacial activity and low adsorption loss. Anionic surfactant petroleum sulfonate is synthesized in a single-tube film sulfonation reac...

Technical Support Scams (TSS), which combine online abuse with social engineering over the phone channel, have persisted despite several law enforcement actions. The tactics used by these scammers have evolved over time and they have targeted an ever increasing number of technology brands. Although recent research has provided important insights into TSS, these scams have now evolved to exploit...