In the super-relaxed state of myosin, ATPase activity is strongly inhibited by binding of the myosin heads to the core of the thick filament in a structure known as the interacting-heads motif. In the disordered relaxed state myosin heads are not bound to the core of the thick filament and have an ATPase rate that is 10 fold greater. In the interacting-heads motif the two regulatory light chain...

This paper presents work on the development of a microfluidic device using super-paramagnetic beads for sampling and mixing. The beads are manipulated via an external rotating permanent magnet in a microfluidic channel. Efficient mixing is achieved in a short distance with this method. Modeling shows the variables which influence the mixing are flow rate, bead rotation speed and the bead number...

Introduction Endothelial progenitor cells (EPC) are promising candidates for novel stem cell transplantation strategies to treat cardiovascular diseases. Within this study formations of vascular network structures with super paramagnetic iron oxide (SPIO) loaded EPCs were induced, which is an in vitro correlate of the vasculogenesis process [1]. The resulting endothelial network showed to be an...

We study the effects of dissipation on a randomly dilute transverse-field Ising magnet at and close to the percolation threshold. For weak transverse fields, a novel percolation quantum phase transition separates a super-paramagnetic cluster phase from an inhomogeneously ordered ferromagnetic phase. The properties of this transition are dominated by large frozen and slowly fluctuating percolati...

Background: To date, several imaging techniques to track stem cells are used such as positron emission tomography (PET), single photon emission computed tomography (SPECT), Bioluminescence imaging (BLI), fluorescence imaging, CT scan and magnetic resonance imaging (MRI). Although, overall sensitivity of MRI compared to SPECT and Bioluminescence techniques are lower, but due to high spatial reso...

Ground states and domain walls are investigated with exact combinatorial optimization in two-dimensional random field Ising magnets. The ground states break into domains above a length scale that depends exponentially on the random field strength squared. For weak disorder, this paramagnetic structure has remnant longrange order of the percolation type. The domain walls are super-rough in order...

Introduction: Positive-contrast imaging of super paramagnetic iron oxide (SPIO)labeled cells avoids problems associated with negative contrast such as other signal voids and partial volume effects [1-7]. Many techniques offer 2D imaging with thick slices and long scan times. A fast 3D alternating repetition time (ATR) SSFP [8] method with reliable on-resonant suppression has recently been intro...