Introduction: Magnetic particle imaging (MPI) is a new quantitative tomographic imaging method for measuring the spatial distribution of super-paramagnetic iron-oxide nanoparticles (SPIOs) in real-time [1, 2, 3, 4]. MPI takes advantage of the nonlinear magnetization behavior of the SPIOs. Spatial encoding is achieved by moving a field-free point (FFP) through the field of interest. For moving t...

Genetically-modified T cells expressing chimeric antigen receptors (CAR) exert anti-tumor effect by identifying tumor-associated antigen (TAA), independent of major histocompatibility complex. For maximal efficacy and safety of adoptively transferred cells, imaging their biodistribution is critical. This will determine if cells home to the tumor and assist in moderating cell dose. Here, T cells...

This work focuses on the visualization and quantification of Super-paramagnetic iron oxide nanoparticles (SPIO-NPs) inside macrophages using transmission electron microscope (TEM) images. Macrophages have been extensively used as probes for cell and subcellular structure labeling, as well as for drug and gene delivery. In order to track the macrophages movement inside the body, SPIO-NPs are int...

Background Despite considerable progress in the development of cellbased therapies, targeted delivery to specific tissues particularly those deep in the body where direct injection is not possible has been problematic. Here we show that tumour-conditioned macrophages infected with oncolytic HSV Seprehvir display a classic activated (M1) profile characterized by the expression of pro-inflammator...

Introduction: Magnetic particle imaging (MPI) is a method to determine the spatial distribution of super-paramagnetic iron oxide particles (SPIOs) at potentially high sensitivity, high spatial and high temporal resolution [1,2,3]. For magnetic field generation and particle signal reception, electromagnetic coils are used. In their paper [1], Gleich and Weizenecker proposed a tube-like scanner s...

Magnetic, Mössbauer, and I.R. studies of nanosize particles of Fe and Co species dispersed in a cage of aluminosilicates structure, in relation to syngas (CO+H2) Fischer Tropsch conversion. The difference in the catalytic activity of such species have shown dependancy on their degree of dispersion. The carbonyl impregnation gave ultra-fine Super Paramagnetic Fe3O4, whereas the nitrate impregnat...

Introduction: Magnetic particle imaging (MPI) is a method capable of determining the spatial distribution of super-paramagnetic iron oxide particles (SPIOs) at potentially high sensitivity, high spatial and high temporal resolution [1,2,3]. The feasibility of a single-sided coil arrangement for field generation and reception of the particle signal was shown in [4]. There, the object of interest...

The possibility of a new technique for fabricating nanoparticles from thin films using selective oxidation in an atmosphere mixture of water vapor and hydrogen was investigated. Fe-5wt.%Al films were RF-sputtered and annealed in the atmosphere mixture at 900°C for up to 200 min, in order to oxidize aluminum selectively. Thermodynamics simulation showed that temperatures exceeding 800°C are nece...

Introduction: Magnetic particle imaging (MPI) is a new tomographic method [1] based on the nonlinear response of super-paramagnetic iron oxide (SPIO) nanoparticles. It has promise for fast imaging in the submillimeter range with some advantages in sensitivity, contrast, and cost in comparison with MRI. A static but spatially inhomogeneous field (selection field) and homogeneous oscillating fiel...

Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites in mice. To achieve...