Introduction: Iron oxide nanoparticles, owing to their very small size and superparamagnetic properties, have been considered a potential candidate for several medical applications such as magnetic cell separation, magnetic resonance imaging (MRI), magnetic targeted drug delivery magnetichyperthermia. The present study aimed to synthesize and evaluate the characteristics of super...

Much recent research on nanoparticles has occurred in the biomedical area, particularly in the area of superparamagnetic iron oxide nanoparticles (SPIONs); one such area of research is in their use as magnetically directed prodrugs. It has been reported that nanoscale materials exhibit properties different from those of materials in bulk or on a macro scale [1]. Further, an understanding of the...

Iron oxide nanoparticles were synthesized and coated with silica by conventional coprecipitation method. Silica coated iron oxide nanoparticles were surface functionalized with chitosan. Silica coating and chitosan functionalization were confirmed by FTIR and TG-DTA analysis. XRD pattern revealed that the pure phase of Fe3O4 was retained even after coating. Particles of average size 12 nm were ...

Magnetic nanoparticles are frequently coated with SiO2 to improve their functionality and bio-compatibility in a range of biomedical and polymer nanocomposite applications. In this paper, a scalable flame aerosol technology is used to produce highly dispersible, superparamagnetic iron oxide nanoparticles hermetically coated with silica to retain full magnetization performance. Iron oxide partic...

One of the most important types of liver cancer is hepatocellular carcinoma (HCC). HCC is the fifth most common cancer, and its correct diagnosis is very important. For the quick diagnosis of HCC, the use of nanoparticles is helpful. The major applications of nanoparticles are in medicine for organ imaging. Two methods of liver imaging are X-ray computed tomography (CT) and magnetic resonance i...

We report a simple phase transfer based synthesis route for two novel anisotropic water soluble iron oxide nanoparticle shapes, namely, nanoplates and nanoflowers. The nanoplates and nanoflowers are initially prepared in an organic solvent via a modified ‘‘heat-up’’ method. Then, the crystalline nanoparticles are rendered hydrophilic via sonication in the presence of dextran and water. These na...

AIMS To evaluate the feasibility of loading resting monocytes/macrophages by intravenous (i.v.) injection of fluorescent iron oxide nanoparticles prior to injury and tracking of these cells in the very same animal to myocardial infarction (MI) by magnetic resonance imaging (MRI) and optical imaging. METHODS AND RESULTS Rats were injected with fluorescent iron oxide nanoparticles (10 mg/kg) (n...

The migration of cells within a living organism can be observed with magnetic resonance imaging (MRI) in combination with iron oxide nanoparticles as an intracellular contrast agent. This method, however, suffers from low sensitivity and specificty. Here, we developed a quantitative non-invasive in-vivo cell localization method using contrast enhanced multiparametric MRI and support vector mach...

O G Inorganic Nanoparticles for MRI Contrast Agents R E S By Hyon Bin Na, In Chan Song, and Taeghwan Hyeon* S R E P O R T Various inorganic nanoparticles have been used as magnetic resonance imaging (MRI) contrast agents due to their unique properties, such as large surface area and efficient contrasting effect. Since the first use of superparamagnetic iron oxide (SPIO) as a liver contrast agen...

In order to understand the role of plasma proteins in the rapid liver clearance of dextran-coated superparamagnetic iron oxide (SPIO) in vivo, we analyzed the full repertoire of SPIO-binding blood proteins using novel two-dimensional differential mass spectrometry approach. The identified proteins showed specificity for surface domains of the nanoparticles: mannan-binding lectins bound to the d...