a simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of gemifloxacin mesylate (gem) in the presence of tween 80 in the bulk, farmaceutical dosage forms and human urine at gold nanoparticles modified carbon paste electrode (gncpe). the electrochemical behavior of gem has been investigated by using cyclic voltammetry (cv) and differential pulse...

Nanoparticle formulations offer besides the advantage of passive drug targeting also the opportunity to increase the stability of drugs. KP1019 is a lead ruthenium(III) compound which has been successfully tested in a clinical phase I trial. However, it is characterized by low stability in aqueous solution especially at physiological pH. To overcome this limitation, poly(lactic acid) (PLA) nano...

Objective: Curcumin penetration can be increased by formulating it into the transethosome system. Surfactant is one of components that affect physical properties and vesicles. In this study, a combination two surfactants was used to see effect on curcumin penetration.
 Methods: This study tween 60 span with concentration ratio 0:5 (F1), 1:1 (F2), 2:1 (F3), 1:2 (F4). An evaluation included ...

The structures of micelles of the surfactant polysorbate 80 (Tween 80) in 0-50% aqueous N,N-dimethylformamide (DMF) solutions (pH 7.2, ionic strength 2.44 mM) were investigated by means of small-angle X-ray scattering. At all the tested DMF concentrations, core-shell cylinder micelles formed; that is, increasing the concentration of DMF did not result in changes in the shape of the micelles. Th...

Cinnamon leaf oil contains a high percentage of eugenol and has antimicrobial, antioxidant and antiinflammatory properties. However, the undiluted oil can cause irritation to the skin. Therefore, the aims of this study were to develop and evaluate cinnamon leaf oil nanocream using palm oil. Nanocream base was prepared using different ratios of oil, surfactants and water. The surfactant used wer...

This work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. In-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. Nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared ...

This report shows that, of the Tween series (Tween 20, Tween 40, Tween 60 and Tween 80) of nonionic surfactants adsorbed on gold nanoparticles (NPs), Tween 80 makes the NPs most stably dispersed in aqueous solutions with or without the presence of representative biological molecules, such as nucleic acids or proteins of different sizes, isoelectric points (pIs) and shapes. In addition, the stab...