OBJECTIVE National guidelines do not recommend antibiotics as an asthma therapy. We sought to examine the frequency of inappropriate antibiotic prescribing during US ambulatory care pediatric asthma visits as well as the patient, provider, and systemic variables associated with such practice. PATIENTS AND METHODS Data from the National Ambulatory Medical Care Surveys and National Hospital Amb...

The authors describe a clinical case of successful treatment patient with an ischiorectal abscess complicated by extensive purulentnecrotic phlegmon on the anterior abdominal wall and right thigh. Topical negative pressure wound technique (NPWT) was used. Its combination surgical debridement rational systemic antibiotic therapy has been shown to contribute this life-threatening pathology.

Severe acute pancreatitis is frequently complicated by local and systemic infections resulting in substantial morbidity, mortality, and health care costs. Antibiotic prophylaxis may prevent some infections. We searched for randomized, controlled trials comparing antibiotic prophylaxis with no prophylaxis in patients with acute necrotizing pancreatitis (ANP). Only trials that used antibiotics th...

BACKGROUND The standard therapy of dialysis catheter-related bacteraemia involves both systemic antibiotics and catheter replacement. We reported recently that instillation of an antibiotic lock (highly concentrated antibiotic solution) into the catheter lumen after dialysis sessions, in conjunction with systemic antibiotics, can successfully treat many episodes of catheter-related bacteraemia ...

background and objective: typhoid fever is still a major health problem for which there are limited options for the diagnosis. current diagnostic methods are time consuming with undesirable sensitivity. among newer diagnostic methods, pcr is attractive and could be potentially very helpful in developing countries where systemic salmonella infections are endemic among children but needs to be in...

We report an infant with meningococcal septicaemia and meningitis who had panophthalmitis at presentation that was unresponsive to standard systemic antibiotic treatment but which responded to topical steroid and mydriatic treatment. The pathogenesis may have been immune mediated.

Antibiotic-resistant bacteria are an increasing threat to the effectiveness of antibiotics. The majority of antibiotics are prescribed in primary care settings for upper respiratory tract infections. The purpose of this study was to describe seasonal trends in outpatient antibiotic prescriptions (Rx) in the United States over a 5-year period. This study was a retrospective, cross-sectional obse...

PURPOSE To identify the risk factors associated with fluoroquinolone resistance in patients undergoing cataract surgery. METHODS A total of 1,125 patients (1,125 eyes) who underwent cataract surgery at Veterans Health Service Medical Center from May 2011 to July 2012 were enrolled in this study. Conjunctival cultures were obtained from the patients on the day of surgery before instillation of...

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold for bone repair and delivers antibiotics at high concentrations to the local site of infection. Duration of antimicrobial activity against Staphyloc...

Acne fulminans (AF) is a rare condition and the most severe form of acne. It is characterized by the sudden onset of painful and ulcerative pustules and systemic symptoms including high fever and polyarthralgia. Response to ordinary antibiotic agents is poor, and the treatment most often recommended is systemic corticosteroids. We report here a case of a young Japanese man with acne fulminans p...