The main objective of the present study was to develop colon targeted drug delivery systems for Nitrofurantoin using guar gum as a carrier. Matrix tablets containing various proportions of guar gum were prepared by wet granulation technique using starch paste as a binder. The in-vitro drug release study was undertaken at 37±0.5°C in 0.1N Hcl for 2 hr; followed by pH 7.4 phosphate buffer (3hr) f...

Introduction Dissolution testing is now an established and standardised method for measuring the performance of drug products (1). It allows results for different batches of the same product,similar products from different suppliers, or tests from different labs to be compared. It is, therefore,a useful tool for quality control and for formulation development,so much so that the FDA has made it...