Parthenolide (PN) is the principal sesquiterpene lactone in feverfew (Tanacetum parthenium) with proven anti-inflammatory properties. We have previously reported that PN possesses strong anticancer activity in ultraviolet B (UVB)-induced skin cancer in SKH-1 hairless mice. In order to further understand the mechanism(s) involved in the anticancer activity of PN, we investigated the role of prot...

The stems and roots of the semiarid shrub guayule, Parthenium argentatum, contain a significant amount of natural rubber. Rubber accumulates in guayule when plants are vegetatively and reproductively dormant, complicating the relationship between growth/reproduction and product synthesis. To evaluate the factors regulating the partitioning of carbon to rubber, carbon assimilation and partitioni...

Phytochemical investigation of Tanacetum parthenium L. family Asteraceae cultivated in Egypt resulted in isolation and identification of four flavonoids. One surface flavonoid was isolated from the fresh leaves and three other flavonoids were isolated from the flower heads. Four sesquiterpene lactones were isolated from the leaves. Two sterols were isolated from the roots. A comparative study o...

Tanacetum parthenium L. known as feverfew is a medicinal herb which is found in many old gardens. It has been used in folk medicine for reducing fever. Feverfew is a member of the daisy family; it is used primarily to prevent migraine headaches and to treat rheumatoid arthritis.It hasa colorless essential oil that contains one or more of the sesquiterpene lactones as active principle. Tanasetum...

The aim of this study was firstly to identify active molecules in herbs, that are traditionally used for the treatment of snake bite, such as Curcuma antinaia, Curcuma contravenenum, Andrographis paniculata, and Tanacetum parthenium; secondly to test similar structurally related molecules and finally to prepare and evaluate an efficient formulation against Ophiophagus hannah venom intoxificatio...

Chemical insecticides application for pest control pose serious impacts on human health and environment. Nowadays, intensified efforts to find safer and environmentally friendly alternatives have resulted in identification and production of some plant-derived natural ingredients that can use against insect pests. Amongst these plants, feverfew, Tanacetum parthenium (L.) Sch.Bip., from Asteracea...

Tanacetum parthenium (feverfew) is an herb that is commercialized worldwide as a therapeutic treatment for migraine. Its pharmacological effect is mainly due to the presence of the sesquiterpene lactone parthenolide as well as of flavonoids. So far, there are no studies on standardization of pre-formulations or phytomedicines containing this herb. The present study aimed at developing a pre-for...