Vitamin B12 (cyanocobalamin, CNCbl) is an essential cofactor-precursor for two biochemical reactions in humans. When ingested, cobalamins (Cbl) are transported via a multistep transport system into the bloodstream, where the soluble protein transcobalamin (TC) binds Cbl and the complex is taken up into the cells via receptor mediated endocytosis. Crystal structures of TC in complex with CNCbl h...

BACKGROUND Germ cell testicular cancer (TC) patients have an increased risk of developing a contralateral TC. This paper presents a retrospective analysis of patients with bilateral TC from a database of a single center and aims to highlight the need for an individual approach. MATERIAL AND METHODS In the study period from January 1970 to June 2013, a total of 1,438 patients with primary TC w...

A Mobile Ad hoc Network (MANET) consists of multiple wireless mobile devices that form a network on the fly to allow communication with each other without any infrastructure. Due to its nature, providing security in these networks is challenging. Threshold Cryptography (TC) provides a promise of securing these networks. In this paper, we discuss our RSA-based Threshold Cryptography (RSA-TC) and...

This study examined longitudinal adoption patterns of tobacco cessation (TC) counseling and TC pharmacotherapy in substance use disorder treatment programs and baseline predictors (program characteristics and program culture) of these patterns 12-months later. Telephone survey data were collected in 2010 from 685 randomly sampled program administrators working in geographically representative t...

(cf. Eqn. (3), (4) of Ref. [1]). Phenomenologically, the coupling term can be motivated in the weak coupling limit by the requirement that it should yield a cos(φ1 − φ2) dependence on the phase difference and not change the free energy if two identical superconductors with the same phase are coupled to each other. For small γ and near Tc, it also reproduces the temperature dependence of the cri...

Sporadic supply interruptions of select radiopharmaceuticals on the global market require consideration of alternative agents to support continuity of essential nuclear medicine examinations. During an acute shortage of Xenon-133 and technetium-99 metastable (Tc-99m) diethylene-triamine-pentaacetate (DTPA), our institution used aerosolized Tc-99m hydroxymethylene diphosphonate (HDP), a radiopha...

I briefly review several key issues in understanding the cuprate superconductors from the point of view of doped-Mott-insulator. Then I present an effective low-energy theory and show that the phase diagram of such a model includes an anti-ferromagnetic (AF) phase, a superconducting state, and a pseudogap phase at low doping and low temperature, consistent with the experimental one. The dual to...

a-Tocopherol (a-TC) and a-TC/cyclodextrin (CD)–inclusion complex (IC) incorporated electrospun poly(lactic acid) (PLA) nanofibers (NF) were developed via electrospinning (PLA/a-TC–NF and PLA/a-TC/g-CD–IC–NF). The release of a-TC into 95% ethanol (fatty food simulant) was much greater from PLA/a-TC/g-CD–IC–NF than from PLA/a-TC–NF because of the solubility increase in a-TC; this was confirmed by...

Background—The myocardial uptake of Tc-sestamibi is attenuated by dobutamine stress, resulting in underestimation of ischemia. N-Ethyl-N-ethoxy-dithiocarbamato-N-Tc (Tc-N-NOET) is a new Tc-labeled perfusion agent that is highly extracted by the myocardium by a mechanism different from that defined for Tc-sestamibi. We therefore hypothesized that Tc-N-NOET uptake would not be attenuated by dobut...

There are two conflicting theories of how plasma vitamin B12 (B12) is transported in man: (a) by two distinct transport proteins, transcobalamins I and II (TC I and II), each having a specific role and time of function; and (b) by three active transport proteins, TC I, II, and III, that take up B12 randomly in proportion to the unsaturated amounts of each. To test these theories a man was given...