Specific delivery of therapeutic agents to solid tumors and their bioavailability at the target site are the most clinically important and challenging goals in cancer therapy. Liposomes are promising nanocarriers and have been well investigated for cancer therapy. In spite of preferred accumulation in tumors via the enhanced permeability and retention (EPR) effect, inefficient drug release at t...

Currently, intelligent, responsive biomaterials have been widely explored, considering the fact that provide controlled and predictable results in various biomedical systems. Responsive nanostructures undergo reversible or irreversible changes presence of a stimulus, stimuli can be temperature, magnetic field, ultrasound, pH, humidity, pressure, light, electric etc. Different types being used d...

Mesoporous silica has emerged as one of the most promising carriers for drug delivery systems. However, the synthesis of ultra-small mesoporous silica nanoparticles (UMSNs) and their application in drug delivery remains a significant challenge. Here, spherical UMSNs (∼25 nm) have been synthesized and tested as drug carriers. Anti-cancer drugs mitoxantrone (MX), doxorubicin (DOX) and methotrexat...

Controlled drug delivery is useful because it allows to obtain better drug product effectiveness, reliability and safety. Interest in stimuli-responsive polymers is steadily gaining increasing momentum especially in the fields of controlled and self-regulated drug delivery. Stimuliresponsive or “smart“ polymers are macromolecules that display a significant physiochemical change in response to s...

The term “nanogel” refers to highly cross-linked hydrogels with a size between 20 and 200 nm. Due their tiny size, they have higher penetration greater drug-loading capacity. They release the medication using mechanisms such as photochemical internalization, volume transition, pH responsiveness, thermo sensitive, photo isomerization. can be categorized according whether respond stimuli or not w...

Mesoporous silica nanoparticles (MSNs) have garnered a great deal of attention as potential carriers for therapeutic payloads. Here, we report a pH-responsive drug-carrier based on chondroitin sulfate functionalized mesostructured silica nanoparticles (NMChS-MSNs) ie, the amidation between NMChS macromer and amino group functionalized MSNs. The prepared nanoparticles were characterized using dy...

With the development of nanotechnology, the application of nanomaterials in the field of drug delivery has attracted much attention in the past decades. Mesoporous silica nanoparticles as promising drug nanocarriers have become a new area of interest in recent years due to their unique properties and capabilities to efficiently entrap cargo molecules. This review describes the latest advances o...

pH-responsive aminolipid self-assemblies are promising platforms for the targeted delivery of antimicrobial peptides (AMPs), with potential to improve their therapeutic efficiency and physico-chemical stability. pH-sensitive nanocarriers based on dispersed 1,2-dioleoyl-3-dimethylammonium-propane (DODAP) human cathelicidin LL-37 in excess water were characterized at different pH values using sma...