Envolvimento do sistema nervoso central na sarcoidose A 51-year-old female patient complained of mild frontotem-poral headache of insidious-onset for two years. One year ago, she had an episode of focal, tonic-clonic seizures (with right lower limb paresthesia) and was prescribed carbamazepine. Cerebrospinal fluid demonstrated increased protein levels and intrathecal im-munoglobulin (IgG) synth...

A LTHOUGH RANDOMIZED TRIALS HAVE BEEN CON­ ducted for several decades now, some aspects of their analysis remain contentious. Two such is­ sues are what to do about trial participants who do not adhere to the protocol (for example, if they do not re­ ceive the intended treatment) and how to deal with those for whom outcome assessments are missing (for example, because they are lost to follow­up...

Limited information and observations indicate that there are some significant amounts of hardwood residue resources now available in the Central Coast area. Experience gained from man­ aging and marketing eastern hardwoods is considered as our basis for dealing with western hardwood problems. Inventory of the oak resource is discussed as a preliminary requirement for management. In ad­ dition, ...

In a stochastic probing problem we are given a universe E, where each element e ∈ E isactive independently with probability pe ∈ [0, 1], and only a probe of e can tell us whether itis active or not. On this universe we execute a process that one by one probes elements —if a probed element is active, then we have to include it in the solution, which we graduallyconstruct. Thr...

Most of the traditional problems in the philosophy of mathematics arise, in 6 James Franklin’s words, out of the ‘oscillation between Platonism and nomi7 nalism, as if those were the only alternatives’ (p. 11). In An Aristotelian Re8 alist Philosophy of Mathematics Franklin develops a tantalizing alternative to 9 these approaches by arguing that at least some mathematical universals exist 10 in...

Recent studies on the impacts of ocean acidification on pelagic communities have identified changes in carbon to nutrient dynamics with related shifts in elemental stoichiometry. In principle, mesocosm experiments provide the opportunity of determining temporal dynamics of all relevant carbon and nutrient pools and, thus, calculating elemental budgets. In practice, attempts to budget mesocosm e...

This meeting was called to ascertain whether cancer is one or many diseases in the opinions of a number of experienced scientists of different dis ciplines. It was hoped that a well documented an swer to this question would serve either to confirm the wisdom of the present policy governing the use of funds for cancer research, or to provide a useful base for a new and different one. An adequate...

Thus, the most efficient way to find genes that have key regulatory functions in vertebrate development is Institute of Neuroscience 1254 University of Oregon to screen for them directly by looking for their mutant phenotypes during embryogenesis. Eugene, Oregon 97403–1254 Two groups have now completed the most extensive genetic screens ever carried out in a vertebrate to isolate mutations in g...

Af ter calling at tention to the lack of observations or of any real effort to determine whether adrenalin or adrenalin-like blood pressure raising substances are present in malignant ren,al hypernephromas, Greer and Wells ( I ) report the results of the examination of two specimens, both of which gave entirely negative results. Examinat ion of the l i terature at my command has not revealed mu...

The Tla locus, situated ~ 1 cent imorgan from H-2D, specifies a number of antigens called T L (thymus leukemia) 1 that are expressed only on thymocytes at an early stage of their differentiation and on some leukemias (1, 2). This locus, which is thought to comprise a series of linked structural and regulatory genes (3), has several unique features. These cannot be reviewed here, but three point...