Gene array analysis has been widely used to identify genes induced during T cell activation. Our studies identified an immediate early gene that is strongly induced in response to IL-2 in mouse T cells which we named cysteineserine-rich nuclear protein-1 (CSRNP-1). The human ortholog was previously identified as an AXIN1 induced gene (AXUD1). The protein does not contain sequence defined domain...

Angela N H Creager, Elizabeth Lunbeck and Londa Schiebinger (eds), Feminism in twentieth-century science, technology, and medicine, Women and Culture in Society, University of Chicago Press, 2001, pp. xii, 264, US$65.00 (hardback 0-226-12023-6), US$20.00 (paperback 0-226-12024-4). Myron Echenberg, Black death, white medicine: bubonic plague and the politics of public health in colonial Senegal,...

Louise Hill Curth (ed.), From physick to pharmacology: five hundred years of British drug retailing, Aldershot, Ashgate, 2006, pp. xii, 174, £50.00 (hardback 0-7546-3597-X; 978-07546-3597-0). Allen G Debus, The chemical promise: experiment and mysticism in the chemical philosophy, 1550–1800: selected essays, Sagamore Beach, Science History Publications/ USA, 2006, pp. xxv, 548, $89.95 (hardback...

Analogues of luteinising hormone-releasing hormone (LHRH) are very much in fashion. Their design is clever and they offer an effective medical alternative to surgical castra-tion in the treatment of breast and prostatic cancer. In breast cancer their use in metastatic disease is increasing steadily, and current enthusiasm is such that multicentre adjuvant therapy trials in early disease are alr...