Cryptorchidism, or maldescended testis, is a common problem encountered in pediatric age groups. Despite more than 100 years of research, many aspects of cryptorchidism are not well defined and remain controversial. However, cryptorchidism clearly has deleterious effects on the testis over time.(1-4)Among the problems associated with an undescended testis are an increased risk for testicular tu...

Bona fide germline genes have expression restricted to the germ cells of the gonads. Testis-specific germline development-associated genes can become activated in cancer cells and can potentially drive the oncogenic process and serve as therapeutic/biomarker targets; such germline genes are referred to as cancer/testis genes. Many cancer/testis genes are silenced via hypermethylation of CpG isl...

The development and secretory activity of testis of lizards is modulated by environmental factors, especially temperature, and it follows a seasonal pattern. Testosterone, secreted by the testis, modulates the functioning of the thymus which governs the immunity of animals. Thymosin is synthesized and secreted by the thymus and governs the development of immunity. At the time when the thymus is...

The ubiquitous isozyme of phosphoglycerate kinase, PGK-1, and the testis-specific isozyme, PGK-2, have been localized to specific cells of the testis by indirect immunofluorescence on Bouin’s fixed testis sections. The earliest cell of the spermatogenic series in which PGK-2 is detectable by immunofluorescence is the Stage 12 spermatid. The intensity of fluorescence increases as the spermatids ...