background: single-nucleotide polymorphism (snp) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (ptpn22) has been shown to be a risk factor for different autoimmune diseases. this study explored the association of 1858 c/t snp with rheumatoid arthritis (ra) and celiac disease (cd) in a region covering south-west of iran. methods: totally, 52 patients with cd, 120 patien...

background interleukine-12 (il-12) induced interferon-γ (ifn- γ) production and development of t cells into th1 cells, which has a critical role in immunity to intracellular pathogens. objectives the current study aimed to evaluate the possible association between il12a rs568408, il12b rs3212227 as well as il-12 receptor (il-12r) rs383483 polymorphisms and pulmonary tuberculosis (ptb). methods ...

The Amplification Refractory Mutation System (ARMS) has been successfully applied to the detection of apolipoprotein (apo) E genotypes in human DNA extracted from peripheral blood. By using four allele-specific oligonucleotide primers and one common primer, one can identify the three common alleles of the apo E genetic polymorphism, epsilon 2, epsilon 3, and epsilon 4. The system amplifies two ...

background: rheumatoid arthritis (ra) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. the aim of the present study was to investigate the impact of cd226 rs727088 and rs763361 polymorphisms and susceptibility to ra in a sample of the iranian population. methods: this case-control study was carried out on 100 patients with ra and 104 healthy su...

results no significant difference was found between the groups regarding bmht rs3797546 gene polymorphism. the c allele was not associated with ns-cl/p (or = 1.27, 95% ci = 0.85-2.79, p = 0.690). conclusions our data suggested that bmht rs3797546 gene polymorphism was not associated with risk/ protection for ns-cl/p in a sample of iranian population. larger studies are required to validate our ...

Interleukin-18 (IL-18) plays a critical role in immune response, contributing to the pathogenesis and pathophysiology of infectious diseases. Polymorphisms in the IL-18 genes are known to influence expression levels and may be associated with outcome of infections. The objective of this study was to determine whether the presence of IL-18 polymorp...

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...

The amplifi cation refractory mutation system (ARMS), which has also been described as allele-specifi c PCR (ASP) and PCR amplifi cation of specifi c alleles (PASA), is a PCR-based method of detecting single base mutations (Newton et al., 1989). ARMS has been applied successfully to the analysis of a wide range of polymorphisms, germline mutations and somatic mutations. The technique has the ab...

[This corrects the article on p. 70 in vol. 32, PMID: 27051445.].