نتایج جستجو برای: th1 and th2

تعداد نتایج: 16829881  

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998
U Kunzendorf T H Tran S Bulfone-Paus

is the production of IL-12 by macrophages and dendritic cells responding to antigens or direct infection immune response; transplantation [3]. Polarized Th1 cells produce IL-2, IFN-c, and lymphotoxin. These cytokines promote the development of cytotoxic T cells, which support delayed-type hypersensitivity reaction (DTH) and facilitate anti-body-dependent cellular cytotoxicity (ADCC) serving Twe...

Journal: :iranian journal of pathology 2012
safyeh soufian arezoo aghakhani minoo mohraz mohammad banifazl ali eslamifar

background and objectives: infection with human immunodeficiency virus (hiv) results in dysregulation of the cytokine profile. a switch from a t helper 1 (th1) to a th2 cytokine has been proposed as an important factor in progression of hiv infection to aids. the aim of the present study was to assess the level of th1 and th2 cytokines in hiv infected individuals in order to identify the switch...

Journal: :Journal of immunology 2005
Takahiro Yasumi Kenji Katamura Ikuo Okafuji Takakazu Yoshioka Taka-Aki Meguro Ryuta Nishikomori Takashi Kusunoki Toshio Heike Tatsutoshi Nakahata

Th1 and Th2 cells mutually antagonize each other's differentiation. Consequently, allergen-specific Th1 cells are believed to be able to suppress the development of Th2 cells and to prevent the development of atopic disorders. To determine whether a pre-existing Ag-specific Th1 response can affect the development of Th2 cells in vivo, we used an immunization model of Ag-pulsed murine dendritic ...

Atherosclerosis is a complex inflammatory disorder of the medium and large-sized arteries. Recent experiments demonstrated that atherosclerosis is a Th1 dominant autoimmune condition, whereas Th2 cells are rarely detected within the atherosclerotic lesions. Several studies have indicated that Th2 type cytokines could be effective in the reduction and stabilization of atherosclerotic plaque. The...

Journal: :The Journal of Experimental Medicine 2000
Hyun Jun Lee Naofumi Takemoto Hirokazu Kurata Yumiko Kamogawa Shoichiro Miyatake Anne O'Garra Naoko Arai

Committed T helper type 1 (Th1) and Th2 effector cells, resulting from chronic antigenic stimulation in interleukin (IL)-12 and IL-4, are implicated in the pathology of autoimmune and allergic diseases. Committed Th1 cells cannot be induced to change their cytokine profiles in response to antigenic stimulation and Th2 cytokine-inducing conditions. Here, we report that ectopic expression of GATA...

2018
Carolina Firacative A Elisabeth Gressler Kristin Schubert Bianca Schulze Uwe Müller Frank Brombacher Martin von Bergen Gottfried Alber

Cryptococcosis, caused by Cryptococcus neoformans, has been demonstrated to be controlled by T helper (Th)1 cells while Th2 cells are associated with fungal growth and dissemination. Although cryptococcal immunoreactive protein antigens were previously identified, their association with Th1 or Th2 immune responses was not provided. In mice, Th1-dependent IFN-γ induces the production of IgG2a, w...

Journal: :iranian journal of immunology 0
bijan khademi cancer immunology group, shiraz institute for cancer research, school of medicine marziyeh tajvarpour cancer immunology group, shiraz institute for cancer research, school of medicine zahra mojtahedi cancer immunology group, shiraz institute for cancer research, school of medicine mohammad reza haghshenas cancer immunology group, shiraz institute for cancer research, school of medicine nasrollah erfani cancer immunology group, shiraz institute for cancer research, school of medicine

background: salivary gland tumors are among malignancies that have high recurrence rate. immune responses in salivary gland tumors have not been well elucidated. t helper type 1 (th1) and th2 cytokines have been reported to play a role in the outcome of head and neck cancers. objective: to evaluate the serum levels of interferon gamma (ifn- γ), as the hallmark of th1 cytokines, and interleukin-...

Journal: :The Journal of Experimental Medicine 1998
Damo Xu Woon Ling Chan Bernard P. Leung David Hunter Kerstin Schulz Robert W. Carter Iain B. McInnes John H. Robinson Foo Y. Liew

Interleukin (IL)-18 induces interferon (IFN)-gamma synthesis and synergizes with IL-12 in T helper type 1 (Th1) but not Th2 cell development. We report here that IL-18 receptor (IL-18R) is selectively expressed on murine Th1 but not Th2 cells. IL-18R mRNA was expressed constitutively and consistently in long-term cultured clones, as well as on newly polarized Th1 but not Th2 cells. IL-18 sustai...

Journal: :The Journal of Experimental Medicine 1988
R Fernandez-Botran V M Sanders T R Mosmann E S Vitetta

Murine Th1 and Th2 subsets differ not only in the lymphokines they produce, but also functionally. It is not clear what factors influence the preferential activation of one subset versus the other and what regulatory interactions exist between them. The purpose of this study was to examine the effect of lymphokines produced by clones of Th1 cells (IL-2 and IFN-gamma), Th2 cells (IL-4), and APC ...

Journal: :Blood 2005
Keita Minami Yoshiki Yanagawa Kazuya Iwabuchi Nobuo Shinohara Toru Harabayashi Katsuya Nonomura Kazunori Onoé

The ability of extracellular stimuli to modulate dendritic cell (DC) activation of natural killer T (NKT) cells was not well understood. We investigated the effects of the T helper type 1 (Th1)/Th2-cytokine environment on DC induction of NKT cell-mediated cytokine production in mice. Pretreatment of myeloid DCs with Th1 or Th2 cytokines, interleukin (IL)-4 or interferon (IFN)-gamma, led to the ...

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