Background: Natural coumarins group, a principal member of the benzopyrone family, is one naturally occurring substances obtained ordinarily from plant origins, with antibacterial, anticoagulant, antihypertensive, anticancer, antioxidant, anti-inflammatory, and many other medicinal potentials. Because are found in nuts, seeds, fruits, vegetables, tea, coffee, wine, average person consumes signi...

This article presents a review of the scientific literature on nutritional value topinambur (Jerusalem artichoke) and its potential use in formulation food products. The covers chemical, amino-acid, vitamin, mineral composition topinambur, pharmacological therapeutic prophylactic effect human organism. distinctive features are content more than 20% dry substances, among which up to 80% contains...

Data on 7,424 soldier spouse abuse offenders were analyzed to determine the prevalence of substance use during abusive incidents, and to examine differences between substance-using and non-substance-using offenders. Results showed that 25% of all offenders used substances during abusive incidents, with males and non-Hispanic Whites being more likely to hav e used substances. Substance-using off...

The huge potential of echinoderms as a so far fairly untapped source of bioactive molecules is described. Examples are presented that show the usefulness of echinoderm-derived molecules for therapeutic application in selected fields of cancer research, in the control of bacterial growth as substances with new antibiotic properties, and finally in the context of technical applications such as an...

The endothelium is more than just a passive interface between the blood and the vessel wall. Since the pioneering discovery of nitric oxide as an important endothelium-derived vasorelaxing molecule three decades ago, vascular research has developed exponentially and remains fascinating for the entire research community. Endothelial dysfunction is a pathological condition characterized by an imb...

the current study is focused on determination of the accumulation rate of cadmium (cd) and lead (pb) in the liver and muscle tissues of the caspian kutum fish. specimens were collected randomly from twelve stations in mazandaran province, the caspian sea basin, between october 2009 and march 2010. fork length, weight and length-weight relationship of samples were measured. one-way analysis of v...

Several QSAR models have been developed using a linear optimization approach that enabled distinguishing metabolic substances isolated from human-, bacterial-, plant- and fungal- cells. Seven binary classifiers based on a k-Nearest Neighbors method have been created using a variety of 'inductive' and traditional QSAR descriptors that allowed up to 95% accurate recognition of the studied groups ...

The therapeutic effect of different ratios of a combination of vincristine and Adriamycin was compared to monotherapy with both substances in advanced rat leukemia L5222. The combination therapy proved to by synergistic. In the upper dose range, no additive toxicity was observed. The combination of 25% vincristine plus 75% Adriamycin effected the best results. In a clinically relevant dose rang...

Neutrophil extracellular traps (NETs) have been suggested to play a pathophysiological role in several autoimmune diseases. Since NET-formation in response to several biological and chemical stimuli is mostly ROS dependent, in theory any substance that inhibits or scavenges ROS could prevent ROS-dependent NET release. Therefore, in the present comprehensive study, several antioxidative substanc...