نتایج جستجو برای: therapeutic substitution
تعداد نتایج: 407128 فیلتر نتایج به سال:
BACKGROUND Cost sharing is widely used to encourage therapeutic substitution. This study aimed to examine the impact of increases in patient cost-sharing differentials for brand name and generic drugs on statin utilization on entry into the Medicare Part D coverage gap. METHOD AND RESULTS Using 5% Medicare Chronic Condition Warehouse files from 2006, this quasi-experimental study examined pat...
Enterotoxigenic Escherichia coli associated with human diarrheal disease utilize any of a limited group of serologically distinguishable pili for attachment to intestinal cells. These include CS1 and CFA/I pili. We show here that chemical modification of arginyl residues in CS1 pili abolishes CS1-mediated agglutination of bovine erythrocytes, which serves as a model system for attachment. Alani...
Understanding the structural and assembly dynamics of the amyloid β-protein (Aβ) has direct relevance to the development of therapeutic agents for Alzheimer's disease. To elucidate these dynamics, we combined scanning amino acid substitution with a method for quantitative determination of the Aβ oligomer frequency distribution, PhotoInduced Cross-linking of Unmodified Proteins (PICUP), to perfo...
OBJECTIVE Automatic therapeutic substitution (ATS) is a mechanism that, upon patient hospitalization, prompts the pharmacist to exchange an equivalent formulary drug for a nonformulary medication, typically without prescriber contact. In facilities utilizing ATS, there is the possibility that physicians and patients may be unaware of the substitution, potentially leading to drug-drug interactio...
The main purpose of this research was to determine the influence a therapeutic dose an opioid drug (methadone) on selected auditory functions in patients addicted opioids (recognition ICD-10; F11) and undergoing substitution therapy. Various hearing tests were used – pure tone audiometry, impedance otoacoustic emission measurement, speech noise test two sessions, before after methadone intake. ...
objective: silicon is an effective element in bone biomineralization; hence si-substituted hydroxyapatite can be a relevant bioceramic as bone materials substitution. materials and methods: stoichiometric hydroxyapatite (ha) and si-substituted hydroxyapatite (si-ha) with different contents of si substitution were synthesized successfully by a hydrothermal method using ca(no3)2, (nh4)3po4 or (n...
Ileal orthotopic bladder substitution has become one of the main therapeutic options following radical cystectomy for invasive bladder cancer. While careful patient selection and the surgical technique are necessary to obtain good long-term results and a satisfactory quality of life, postoperative management is also of utmost importance. It includes successful voiding rehabilitation (micturitio...
The kinetics of substitution of [Ti(ur)6]3+ by H2O and SCN¯ ion in ethanol solution have been measured spectrophotometrically by stopped-flow method. Water is a good nucleophile toward Ti(III) substrates. Even the solvent ethanol appears to be a poor ligand when compared to water. Substitution, in general follows two parallel pathways: "direct" (second order...
Despite the body of research on textbook evaluation from the discourse analysis perspective, cohesive devices have rarely been analyzed in English for Specific Purposes (ESP) textbooks. The acquisition and use of cohesive devices is inherent to naturalistic communication, including business interactions. Hence, L2 learners of business English should be exposed to these devices through cohesion-...
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