A resorufin–dinitrophenyl ether conjugate (1) shows emission enhancement for aromatic thiols in aqueous media with a neutral–basic pH, while being nonemissive for aliphatic thiols. This is achieved by two electrophilic sites with different local softness on compound 1; the respective sites selectively react with aromatic or aliphatic thiolate anions.

Alcohols, trimethylsilyl ethers and thiols were efficiently converted to their corresponding carbonyl and disulfides compounds using o-xylylenebis (triphenylphosphonium) dibromochromate (XTPPDBC). This reagent can selectively oxidize thiols to disulfides in the presence of alcohols and trimethylsilyl ethers in acetonitrile at room temperature.

Introduction: There have been several reports on levels of GST and thiol status in hepatocellular damage. Very few comparative studies are available to know the levels of GST and thiols in various disorders causing hepatocellular damage. Current study was undertaken to know serum GST activity and total thiols status in patients with various disorders causing liver damage. Subjects and methods: ...

It is widely accepted that the redox status of protein thiols is of central importance to protein structure and folding and that glutathione is an important low-molecular-mass redox regulator. However, the total cellular pools of thiols and disulfides and their relative abundance have never been determined. In this study, we have assembled a global picture of the cellular thiol-disulfide status...

Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Metho...

Nano sized indium oxide is found to be an efficient catalyst for the conversion of thiols to sulfides using Na2CO3 as base and TBATB as reagent in DMSO at 110 °C. Here in situ generation of bromo intermediate by TBATB takes place through indium surface. A variety of aryl sulfides can be synthesized in excellent yields from less reactive chlorides, boronic acids and thiols.

Glycosyl thiols may be accessed from the corresponding reducing sugars in water without recourse to any sugar projecting groups by way of a DMC mediated reaction with thioacetic acid in the presence of base, and hydrolysis of the anomeric thioacetate. Glycosyl thiols produced by this method may be used to access glycoconjugates, such as glycopeptides by use of the thiol-ene click reaction.

A novel way of synthesizing unsymmetrical disulfides from thiols with DDQ is presented here. This procedure ran in a straightforward manner to give high product yields. Unsymmetrical disulfides were directly synthesized from the corresponding mixture of thiols in equimolar amounts under mild conditions. 2011 Elsevier Ltd. All rights reserved.

Judicious design of BODIPY dyes carrying nitroethenyl substituents in conjugation with the BODIPY core yields dyes that respond to biological thiols by both absorbance and emission changes. Incorporation of solubilizing ethyleneglycol units ensures water solubility. The result is bright signaling of biologically relevant thiols in the longer wavelength region of the visible spectrum and in aque...

The spatiotemporal chemical characteristics of the water column in Linsley Pond, a freshwater lake in Connecticut, were studied from just before its stratification in April through the fall turnover in December. Two low-molecular-weight thiols, glutathione and 3-mercaptopropionic acid (MPA), were detected at nanomolar concentrations in the water column. GSH was detected (average concentrations ...