The dose-related response of the mammary growth was studied in immature ICR-JCL female mice given 0.03 micrograms of estradiol per animal subcutaneously, and 0.005-1.0mg of either of the following phenothiazines (chlorpromazine, levometh iomeprazine, promethazine, perphenazine, thioridazine and propericiazine) per 10g of body weight was given orally once a day for 9 days starting on the 5th day...

A spectrophotometric method was used to follow the oxidation of retinol by preparations of cattle retinas. Two-tenths millimole chlorpromazine (CPZ) and thioridazine (TRDZ) activated the initial rate. This was followed by inhibition. These effects are reversible. The ring sulfoxide of chlorpromazine and thioridazine thiomethyl sulfoxide (TPS-23) had no apparent effect. Lower concentrations (0.0...

A 10-year cohort study found a 1.33-fold relative risk of death in a schizophrenic population compared with a control population; the leading cause of death was cardiovascular disease. In patients with myocardial infarction and cardiac failure, reduced heart rate variability is one of the predictive factors of increased risk of cardiac death; this reduced heart rate variability might be due to ...

OBJECTIVE The aim of the present study was to examine the relationship between serious arrhythmias in patients with psychotropic drug overdose and electrocardiography (ECG) findings that have been suggested previously to predict this complication. METHODS Thirty-nine patients with serious arrhythmias (ventricular tachycardia, supraventricular tachycardia or cardiac arrest) after tricyclic ant...

The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of rat CYP2B measured as a rate of 16 beta-hydroxylation of testosterone. The reaction was studied in control liver microsomes in the presence of neuroleptics, as well as in microsomes of rats treated intraperitoneally for one day or two weeks (twice a day) with pharmacological dos...

The phenothiazine derivatives such as: promethazine, chlorpromazine and thioridazine hydrochlorides are used as psychotropic, neuroleptic, local anesthetics, anti-allergic and antiyomiting drugs [1]. The therapeutic interest in these compounds group justifies research to establish different analytical methods for the determination of these drugs in pharmaceutical preparations and biological sam...