The asymmetric unit of the title compound, C(8)H(9)N(3)O(2)S·0.5H(2)O, contains two thiosemicarbazide mol-ecules with the short distance of 3.521 (3) Å between the centroids of the benzene rings, and one water mol-ecule. In the two independent mol-ecules, the benzene rings and the thio-semicarbazone fragments are twisted at 9.2 (3) and 18.5 (3)°. An extensive three-dimensional hydrogen-bonding ...

Thiazoles and thiazolyl-pyrazole derivatives have been efficiently synthesized under neat reaction conditions in excellent yields. Condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one (1), thiosemicarbazide (2) and various carbonyl compounds (3 & 5) gave corresponding thiazole (4) and thiazolylpyrazole derivatives (6) in excellent yields by using Hantzsch-Thiazole synthesis. The ...

A series of 4-arylthiosemicarbazides substituted at the N1 position with a 5-membered heteroaryl ring was synthesized and evaluated in vitro for T. gondii inhibition proliferation and host cell cytotoxicity. At non-toxic concentrations for the host cells all studied compounds displayed excellent anti-parasitic effects when compared to sulfadiazine, indicating a high selectivity of their anti-T....

New 5-[1-(anthracen-9(10H)-ylideneamino)-2-(1H-imidazol-5-yl)ethyl]-1,3,4-thiadiazol-2-amine 3 has been synthesized from condensation reaction of N-anthracen-9(10H)-ylidenehistidine 2 with thiosemicarbazide in phosphorusoxy chloride. The prepared compounds were characterized by FTIR spectroscopy, electronic spectroscopy, NMR and NMR. Preliminary in vitro tests for fungicidal activity show that ...

Some new substituted benzaldehyde (2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl) thiosemicarbazones were synthesised by reaction of 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl thiosemicarbazide and different substituted benzaldehydes. The reaction was performed using conventional and microwave-assisted heating methods. The structures of thiosemicarbazones were confirmed by spectroscopic (IR, (1)...

In the reaction of hydrazide of 3,4-dimethoxyphenylacetic acid (1) with isothiocyanate the respective thiosemicarbazide derivatives (2) were obtained. Further cyclization with 2% NaOH led to the formation of 3-[(3,4-dimethoxyphenyl)methyl]-4-substituted-1,2,4-triazoline-5-thiones (3). The structures of all new products were confirmed by analytical and spectroscopic methods. All compounds were s...

A rapid and reproducible method is described for measurement of urea in biological materials (after deproteinisation) and in serum (without deproteinisation). Urea is colorimetrically determined with diacetyl monoxime and thiosemicarbazide in the presence of sulphuric acid, phosphoric acid and ferric chloride. The sensitivity of the colorimetric reaction and stability of the colour are enhanced...

Purpose: To synthesize thiosemicarbazide and determine its antimicrobial properties. Methods: Pyridine-based thiosemicarbazide was synthesized, characterized and evaluated for antimicrobial activity. The structure of the synthesized compound was established by spectral analysis, namely, Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H NMR), car...

In the present work, an adsorptive stripping voltammetric method using a hanging mercurydrop electrode (HMDE) was described in order to determine the ultra trace of thiosemicarbazidein different real samples. The method is based on accumulation of thiosemicarbazide on mercuryelectrode. The potential was scanned to the negative direction and the differential pulse strippingvoltammograms were rec...

P. Souza3 *, A. I. Matesanz3, A. Arquerob, V. Fernandez3 a Departamento de Qmmica (C -V III), Facultad de Ciencias, Universidad Autönoma de Madrid, Cantoblanco, E-28049-Madrid, Spain b Departamento A.T.S.I., Facultad de Informätica, Universidad Politecnica de Madrid, Montegancedo s/n, E-28660-Boadilla del Monte, Madrid, Spain Z. Naturforsch. 49b, 665-671 (1994); received January 19, 1994 Triazo...