New thiosemicarbazide derivatives 2-6 were synthesised by reacting 2-(ethylsulfanyl)benzohydrazide with various aryl isothiocyanates. The cyclisation of compounds 2-6 under reflux conditions in a basic medium (aqueous NaOH, 4 N) yielded compounds 7-11 that contain a 1,2,4-triazole ring. All of the synthesised compounds were screened for their antioxidant activities. Compounds 2, 3, and 7 showed...

We have been interested for some time in thiosemicarbazide derivatives of periodate-oxidized polysaccharides many of which show considerable activity against Sarcoma 180 (S-180) in the mouse (2). The antitumor activity and toxicity of these deriva tives are completely reversed if pyridoxine (B6) is administered at the same time. We were led to investigate glyoxal and methylglyoxal bisthiosemica...

Three novel thiosemicarbazone O-carboxymethyl chitosan derivatives were obtained via a condensation reaction of thiosemicarbazide O-carboxymethyl chitosan with o-hydroxybenzaldehyde, p-methoxybenzaldehyde, and p- chlorobenzaldehyde respectively. Their structures were characterized by elemental analysis, FTIR, (13)C NMR and X-ray diffraction. The antimicrobial behaviors of the prepared derivativ...

A series of novel glycosylthiadiazole derivatives, namely 2-phenylamino-5-glycosyl-1,3,4-thiadiazoles, were designed and synthesized by condensation between sugar aldehydes A/B and substituted thiosemicarbazide C followed by oxidative cyclization by treating with manganese dioxide. The original fungicidal activities results showed that some title compounds exhibited excellent fungicidal activit...

Bis diacetylpyridine derivative (1) was prepared and reacted with different halo-compounds, namely: epichlorohydrine and dichloroethyl ethyl ether to give 2a,b, respectively, and reacted with morpholine and piperidine to afford Mannich products 3a,b, successively. Compound 4 was synthesized by reaction of 1 with potassium thiocyanate. Reaction of 4 with 4-chlorobenzaldehyde, glucose and phthali...

2-Amino-5-(2-aryl-2H-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles 2-4 have been synthesized by the reaction of 2-aryl-2H-1,2,3-triazole-4-carboxylic acids 1 with thiosemicarbazide. Their reaction with phenacyl (p-substituted phenacyl) bromides led to formation of the respective 6-aryl-2-(2-aryl-2H-1,2,3-triazol-4-yl)imidazo[2,1-b]-1,3,4-thiadiazoles 5. Reactivity of the latter fused ring towards reac...

A series of substituted N-(Benzylidineamine)-3-cycloalkylidine-thiosemicarbazide derivatives have been synthesized, characterized and evaluated for their antifungal and antibacterial activities. The newly synthesized compounds were characterized by IR, NMR, Mass and elemental analysis. All compounds were tested for antifungal and antibacterial activities. The preliminary results revealed that s...

A series of metal complexes of Ni(II), and Cu(II) having the general composition [M(L)(2)X(2)] with thiosemicarbazide have been prepared and characterized by elemental chemical analysis, molar conductance, magnetic susceptibility measurements, mass, IR, electron paramagnetic resonance, and electronic spectral studies. The IR spectral data suggest the involvement of sulfur and terminal amino nit...

Iron homeostasis is altered in tumours response to a perturbation the expression of iron-dependent proteins. Therefore, iron chelators make cancerous cells more vulnerable deficiency. Compounds having thiosemicarbazide scaffold with ability metal complex formation have potential act as anticancer. A series derivatives were designed, synthesized successfully and their cytotoxicity was then teste...

The reactions of transition metal salts with monofunctional bidentate thiosemicarbazone (TSCZH) derived from the condensation of 6-nitro-1H-indole 2-3 dione with thiosemicarbazide have been carried out in 1:2 molar ratio. Derivatives of the type [M(TSCZH)2 .xH2O] Cl (where M=Ti (III), V (III), Mn (III), Co (III), Ru (III), Fe (III) Mo O2(V) and Mo O2(VI) have been obtained. All these complexes ...