primary immune thrombocytopenia is an acquired bleeding disorder with no clinically apparent cause of thrombocytopenia. clinical indicators of itp include easy bruising of the skin, prolonged bleeding on injury, mucocutaneous lesions such as petechiae and ecchymosis, epistaxis, gastrointestinal bleeding, hematuria and bleeding from the gums. it is important for a dentist to be aware of the clin...

coincidence of autoimmune diseases such as immune thrombocytopenic purpura (itp) with  immunodeficiencies has  been  reported  previously in  patients  who  suffered  from primary antibody deficiency (pad). but there is no original study on immunological profiles of itp patients to find out their probable immune deficiency. in this case-control study, itp patients’ humoral immunity was investig...

background: immune thrombocytopenic purpura (itp) is an autoimmune disease that can cause bleeding disorders in patients, and presents in acute and chronic forms. the acute form is frequently seen in children, but the chronic form mainly inflicts adults. there are differences and similarities in clinical and laboratory findings of the disease between children and adults. we study these differen...

background this study aimed to evaluate the effectiveness of intravenous immunoglobulin (ivig) and combination of ivig and methylprednisolone for childhood idiopathic (autoimmune) thrombocytopenia (itp) treatment; in addition investigate the related factors to develop chronic form of under 15 years itp. materials and methods this retrospective study conducted on 88 itp patients that treated wit...

bakcground: the aim of itp treatment is to prevent intracranial hemorrhage and increase the platelet count rapidly. this study was conducted with the objective of comparing the efficacy of anti-d immunoglobulin (ig) with dexamethasone in treating childhood itp. materials and methods: in this randomized prospective control trial, 20 itp patients (platelet count< 20,000/µl) younger than 16 were s...

background: children with idiopathic thrombocytopenic purpura who are treated with intravenous immunoglobulin therapy might experience a decline in their absolute neutrophil count. the aim of this study was to investigate the incidence of neutropenia following intravenous immunoglobulin therapy in children with idiopathic thrombocytopenic purpura undergoing intravenous immunoglobulin therapy. p...

mental stress and daily crises comprise a part of physical and mental threats. perceived stress is a physical and mental threat, as well. perceived stress is a psychological process during which the individual considers his/ her physical and psychological welfare as being threatened. since idiopathic thrombocytopenic purpura (itp) is one of the chronic diseases being able to affect patients' pe...

Untreated human immunodeficiency virus (HIV) can be complicated by opportunistic infections, including disseminated histoplasmosis (DH). Although endemic to portions of the United States and usually benign, DH can rarely act as an opportunistic infection in immunocompromised patients presenting with uncommon complications such as acute kidney injury and idiopathic thrombocytopenic purpura. We r...

A case of thrombotic thrombocytopenic purpura in a patient with a recent flare of cerebral lupus is presented. The patient presented with neurologic symptoms, pyrexia, thrombocytopenia and leucocytosis. Following initial investigation, imaging of brain and negative microbiology, a diagnosis of cerebral lupus was made and appropriately treated. After a stable period oftwo weeks, deterioration in...

Bianchi, V., Robles, R., Alberio, L., Furlan, M. & Lammle, B. (2002) Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders: a severely deficient activity is specific for thrombotic thrombocytopenic purpura. Blood, 100, 710–713. Coppo, P., Bengoufa, D., Veyradier, A., Wolf, M., Bussel, A., Millot, G.A., Malot, S., Heshmati, F., Mira, J.P., Boulanger, E., Galicier, L., ...